2014
DOI: 10.1080/10826076.2013.836712
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Isolation, Identification, and Characterization of 17-Oxo Dexamethasone, an Oxidative Degradation Impurity of Dexamethasone Using Flash Chromatography and NMR/HRMS/Ir

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Cited by 9 publications
(2 citation statements)
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“…These oxidative processes are enhanced by elevated temperature or light exposure [34]. 17-oxo-DEX has been reported as a major degradation product of oxidation under basic stress conditions [35][36][37]. Water is eliminated from DEX after the C 20 keto group is converted into an enol group [36,38].…”
Section: Discussionmentioning
confidence: 99%
“…These oxidative processes are enhanced by elevated temperature or light exposure [34]. 17-oxo-DEX has been reported as a major degradation product of oxidation under basic stress conditions [35][36][37]. Water is eliminated from DEX after the C 20 keto group is converted into an enol group [36,38].…”
Section: Discussionmentioning
confidence: 99%
“…The utilization of stress testing can facilitate a more comprehensive comprehension of the degradation products of a medicinal product and the intrinsic stability of its molecule [13][14][15][16][17][18][19][20][21][22][23]. Therefore, both the sample and the placebo were subjected to varying levels of stress, as elaborated upon thereafter.…”
Section: Stress Studiesmentioning
confidence: 99%