Isolation, identification, and epidemiological characteristics of goose astrovirus causing acute gout in Guangdong province, China

Xiang, Yong; Chen, Meiting; Sun, Minhua; Dong, Jiawen; Zhang, Junqin; Huang, Yunzhen; Zhai, Qi; Liao, Ming; Li, Linlin

doi:10.1016/j.psj.2024.104143

Poultry Science

2024

DOI: 10.1016/j.psj.2024.104143

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Isolation, identification, and epidemiological characteristics of goose astrovirus causing acute gout in Guangdong province, China

Yong Xiang,

Meiting Chen,

Minhua Sun

et al.

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2024

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Cited by 2 publications

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Isolation and characterization of goose astrovirus genotype 1 causing enteritis in goslings from Sichuan province, China

Chen,

Zhang

2024

Preprint

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Since 2017, Goose astrovirus (GoAstV) has been widely prevalent in various provinces of China, leading to substantial economic losses in the goose industry. This study documents an outbreak of infectious disease in 1–3 week-old goslings on a goose farm in Sichuan, characterized by enteritis and a mortality rate of approximately 30%. Viral metagenomic sequencing of fecal samples identified the infection as Goose Astrovirus genotype 1 (GoAstV-1). PCR analysis further confirmed GoAstV-1 in liver tissues from deceased goslings, and a GoAstV-1 strain was successfully isolated from goose embryos. The full genome of the isolated strain, named Goose Astrovirus AAstV/Goose/CHN/2023/C1 (GenBank No. PP108251), was obtained through segmental amplification, sequencing, and assembly. Phylogenetic analysis revealed that the isolate belongs to GoAstV-1 subtype B. Experimental inoculation of one-day-old goslings with the virus (10− 4.834 ELD50/0.5 mL) resulted in a mortality rate of 5 out of 15 and a reduction in growth rates. Pathological examination indicated viral damage to the intestines, liver, spleen, and kidneys. These findings contribute to a deeper understanding of the genetic evolution and pathogenicity of GoAstV-1 and provide critical insights for disease prevention and control strategies in Sichuan province.

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Isolation and characterization of goose astrovirus genotype 1 causing enteritis in goslings from Sichuan province, China

Chen,

Zhang

2024

Preprint

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Metagenomics analysis of viruse populations from feces of diarrheal geese in Sichuan Province

Chen,

Ma,

Zhang

2024

Preprint

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In recent years, novel viruses have brought serious economic losses to the goose industry. In this study, we performed viral metagenomics analysis on fecal samples from sick geese with clinical symptoms of diarrhea in a goose farm in Sichuan, China. The results showed that six viruses belonging to four virus families were identified in the fecal samples, including goose calicivirus, a member of the proposed genus sanovirus in the family Caliciviridae; two novel species in Picornaviridae, goose megrivirus and goose picornavirus; goose astrovirus type 1, a lesser-reported member of goose astrovirus; and partial segments of Rotavirus F and Rotavirus G. All of these viruses are associated with avian diarrhea and may be the pathogens causing diarrhea in geese on this farm. This research enhances the diversity of viruses that infect geese and serves as a valuable reference for the prevention and control of goose diseases.

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Isolation, identification, and epidemiological characteristics of goose astrovirus causing acute gout in Guangdong province, China

Cited by 2 publications

References 22 publications

Isolation and characterization of goose astrovirus genotype 1 causing enteritis in goslings from Sichuan province, China

Isolation and characterization of goose astrovirus genotype 1 causing enteritis in goslings from Sichuan province, China

Metagenomics analysis of viruse populations from feces of diarrheal geese in Sichuan Province

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