Isolation of a new okadaic acid analogue from phytoplankton implicated in diarrhetic shellfish poisoning

Draisci, Rosa; Giannetti, Luigi; Lucentini, Luca; Marchiafava, C.; James, Kevin J.; Bishop, Alan; Healy, Brendan M; Kelly, Sarah

doi:10.1016/s0021-9673(97)01200-4

Cited by 41 publications

(16 citation statements)

References 29 publications

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“…However, it should be noted that these allylic diol esters may be somewhat labile and could be hydrolysed to yield the active parent DSP toxin (Hallegraeff et al, 1995). Draisci et al (1998) reported the detection of another OA isomer and called it DTX2C. The structure of DTX2C is not yet elucidated.…”

Section: Chemical Propertiesmentioning

confidence: 99%

Marine biotoxins and its detection

Suresh¹,

Gauri²,

Desai³

et al. 2014

Afr. J. Environ. Sci. Technol.

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The incidences of intoxication due to the consumption of marine foods have been increasing in recent years. This is due to the presence of biotoxins in foods of marine origin. The biotoxins will be accumulated in the marine foods due to the consumption of toxic biota of marine origin. When this contaminated food is taken by the humans or animals, those toxins will be transferred to them causing intoxication and lethality. Among these intoxications, most of them are caused by the harmful algal blooms (HAB). In order to avoid the harmful effects from marine biotoxins, it is necessary to have the proper knowledge. In this manuscript, the different types of biotoxins, source of intoxication, characteristics of toxins, detection and control measures are discussed in detail.

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Section: Chemical Propertiesmentioning

confidence: 99%

Marine biotoxins and its detection

Suresh¹,

Gauri²,

Desai³

et al. 2014

Afr. J. Environ. Sci. Technol.

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show abstract

“…1) (Fernandez et al, 2003;Suarez-Gomez et al, 2001. In addition, two isomers of OA, DTX-2b, and -2c, have been observed in HPLC-MS analysis of phytoplankton extracts (Draisci et al, 1998). These compounds have the same molecular mass and fragmentation pattern as OA, yet have different HPLC retention times.…”

Section: Prorocentinmentioning

confidence: 99%

The Biosynthesis of Polyketide Metabolites by Dinoflagellates

Rein

Snyder

2006

Advances in Applied Microbiology Volume 59

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“…Similar negative ion FIA-MS experiments were also carried out on an OA solution, and here only the deprotonated molecule, [MÀH] À , of OA at m/z 803, was observed for this toxin. 21 In order to obtain further structural information on YTX, CID-MS/MS experiments were then carried out by selecting the precursor ion [MÀ2NaH] À at m/z 1141. Figure 2 shows the negative-ion FIA-MS/MS spectrum (range m/z 500-1300) of a YTX standard solution.…”

Section: (Data Not Shown) the Most Abundant Molecule-related Ion [Mmentioning

confidence: 99%

“…On the basis of the MS/MS fragmentation of YTX and OA, 21 the combination precursor/fragment ions of m/z 1141/1061 and m/z 803/255 were considered suitable for confirmatory YTX and OA analyses, respectively. SRM LC/MS/MS analysis of standard mixtures of YTX and OA is shown in Fig.…”

Section: (Data Not Shown) the Most Abundant Molecule-related Ion [Mmentioning

confidence: 99%

“…On the other hand, liquid chromatography coupled with mass spectrometry and tandem mass spectrometry (LC/MS, LC/MS/MS), using an ionspray interface, has proved to be an excellent analytical approach for confirmatory analysis of known toxins, such as OA and DTXs, [11][12][13][14][15][16][17] PTX 18 and a valuable tool for the detection of new toxins in marine samples. [19][20][21] The aim of this research was to investigate the possibility of using ionspray LC/MS and LC/MS/MS for the identification of YTX in shellfish.…”

mentioning

confidence: 99%

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