Isolation Of Potential Pathogenic Bacteria From Nasopharynx From Patients Having Cough For More Than Two Weeks.

Yesmin, Kazi; Shamsuzzaman, SM; Chowdhury, A. K.; Khatun, Khadeza; Alam, Jahangir

doi:10.3329/bjmm.v4i2.10826

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…The human nasopharynx can be densely colonized with both commensal bacteria and pathogens, including B. pertussis. Infected individuals aerosolize pertussis-containing droplets by coughing or sneezing (260). Studies of infectious disease transmission estimated the basic reproductive number (R 0 ) for various infectious diseases, including pertussis.…”

Section: Transmission Dynamics Of Pertussismentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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SUMMARYPertussis is a severe respiratory infection caused byBordetella pertussis, and in 2008, pertussis was associated with an estimated 16 million cases and 195,000 deaths globally. Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic evolution ofB. pertussisstrains. During the past 20 years, the scientific community has recognized pertussis among adults as well as infants and children. Increased recognition that older children and adolescents are at risk for disease and may transmitB. pertussisto younger siblings has underscored the need to better understand the role of innate, humoral, and cell-mediated immunity, including the role of waning immunity. Although recognition of adult pertussis has increased in tandem with a better understanding ofB. pertussispathogenesis, pertussis in neonates and adults can manifest with atypical clinical presentations. Such disease patterns make pertussis recognition difficult and lead to delays in treatment. Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology. Together, these advances provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines.

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Section: Transmission Dynamics Of Pertussismentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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“…La tos ferina es altamente contagiosa y puede esparcirse rápidamente de persona a persona mediante el contacto con aerosoles producidos al toser o estornudar por el individuo infectado, cuya bacteria se aloja inicialmente en la nasofaringe (23).…”

Section: Clínica De La Enfermedadunclassified

Pertussis: enfermedad reemergente

Vargas

Colma

2017

Rev. Med.

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RESUMENIntroducción: Actualmente a pesar de las estrategias de vacunación a nivel mundial, B. pertussis se ha convertido en un problema de salud pública, sigue siendo una de las enfermedades menos prevenibles por vacunación en todo el mundo, aún en países desarrollados con amplia cobertura de vacunación.Objetivo: Describir los principales mecanismos de virulencia asociados a la infección mediante los cuales la bacteria logra evadir la respuesta inmune, además de dar a conocer un panorama actual del estado de inmunización contra la tos ferina y la problemática de su reemergencia a nivel mundial.Métodos: Se realizó una revisión mediante búsqueda electrónica de literatura; entre las estrategias de búsqueda se destaca el empleo de las bases de datos como PubMed, ScienceDirect, SciELO, Redalyc; y búsqueda en portales de salud; sobre aspectos generales de la enfermedad y su agente causal, además de últimas actualizaciones sobre el tema.Resultados: Como lo confirman recientes estudios, el incremento del riesgo de infección por B. pertussis sigue presentándose en adolescentes y adultos debido a la disminución en la respuesta inmune inducida por la vacunación y la infección natural, por ende, la información actual indica que está reemergiendo la tos ferina en todo el mundo, situación que es necesario conocer para un oportuno diagnóstico y tratamiento.Conclusiones: Análisis de la literatura demuestra la necesidad de ampliar el uso de técnicas moleculares; llevar a cabo la modificación de los programas de vacunación, con la administración de dosis de refuerzo entre adolescentes y adultos; además programas de monitoreo epidemiológico eficaces de recolección de casos con tos ferina y sistemas adecuados de notificación para lograr la reducción equitativa y sustentable de la morbilidad y mortalidad de ésta enfermedad.Palabras clave: Bordetella pertussis; Adenylate cyclase toxin-hemolysin; cAMP intoxication; Pertussis vaccine; Genetic changes Bordetella pertussis. PERTUSSIS: REEMERGING DISEASE ABSTRACTIntroduction: Currently despite vaccination strategies worldwide, B. pertussis has become a public health problem, it remains one of the least vaccine preventable diseases in the world, even in developed countries with extensive coverage of vaccination. 79Objective: To describe the main mechanisms of virulence associated with the infection through which the bacterium manages to evade the immune response, as well as to present a current picture of the state of immunization against pertussis and the problem of its reemergence worldwide.Methods: Electronic literature search was performed; among the search strategies we highlight the use of databases such as PubMed, ScienceDirect, SciELO, Redalyc; and search in health portals; on general aspects of the disease and its causal agent, in addition to the latest updates on the subject.Results: As confirmed by recent studies, the increased risk of B. pertussis infection continues to occur in adolescents and adult's due to the decrease in the immune response induced by vaccination and natur...

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Bordetella pertussis

Caulfield,

Harvill

2024

Molecular Medical Microbiology

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Isolation Of Potential Pathogenic Bacteria From Nasopharynx From Patients Having Cough For More Than Two Weeks.

Cited by 5 publications

References 25 publications

Pertussis: Microbiology, Disease, Treatment, and Prevention

Pertussis: Microbiology, Disease, Treatment, and Prevention

Pertussis: enfermedad reemergente

Bordetella pertussis

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