Isolation of Putative Biosynthetic Intermediates of Prenylated Indole Alkaloids from a Thermophilic Fungus <i>Talaromyces thermophilus</i>

Chu, Yan-Sheng; Niu, Xue‐Mei; Wang, Yanli; Guo, Jipeng; Pan, Wen-Zheng; Huang, Xiaowei; Zhang, Ke‐Qin

doi:10.1021/ol101817g

Cited by 53 publications

(39 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thermophilic fungi received little attention though strains keyed out as Aspergillus clavatus (Jiang et al ) and Talaromyces thermophilus (Chu et al ; Guo et al ) have been reported.…”

Section: High‐temperature Environmentsmentioning

confidence: 99%

“…), two unusual cyclodepsipeptides containing an anthranilic acid dimer and phenyllactic acid residues were isolated from an A. clavatus strain associated with the thermophilic crab, Xenograpsus testudinatus which lives around the sulphur‐rich hydrothermal vents in Taiwan, these compounds inhibit the proliferation of hepatocellular carcinoma cell lines (HepG2) by arresting their growth at G1 phase (Jiang et al ). Chemical investigation of the thermophilic fungus T. thermophilus afforded two new prenylated alkaloids talathermophilins A and B ( 177 , 178 ) which showed nematicidal toxicity against the parasitic worm Panagrellus redivevus (Chu et al ). Subsequently, four talathermophilins ( 179 – 182 ) were isolated from the same fungus (Guo et al ).…”

Section: High‐temperature Environmentsmentioning

confidence: 99%

See 1 more Smart Citation

Extreme environments: microbiology leading to specialized metabolites

et al. 2019

View full text Add to dashboard Cite

Summary The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the preantibiotic days of medicine at the time of diminishing numbers of drug leads. The good news is that an increased understanding of the nature and extent of microbial diversity in natural habitats coupled with the application of new technologies in microbiology and chemistry is opening up new strategies in the search for new specialized products with therapeutic properties. This review explores the premise that harsh environmental conditions in extreme biomes, notably in deserts, permafrost soils and deep‐sea sediments select for micro‐organisms, especially actinobacteria, cyanobacteria and fungi, with the potential to synthesize new druggable molecules. There is evidence over the past decade that micro‐organisms adapted to life in extreme habitats are a rich source of new specialized metabolites. Extreme habitats by their very nature tend to be fragile hence there is a need to conserve those known to be hot‐spots of novel gifted micro‐organisms needed to drive drug discovery campaigns and innovative biotechnology. This review also provides an overview of microbial‐derived molecules and their biological activities focusing on the period from 2010 until 2018, over this time 186 novel structures were isolated from 129 representatives of microbial taxa recovered from extreme habitats.

show abstract

“…Thermophilic fungi received little attention though strains keyed out as Aspergillus clavatus (Jiang et al ) and Talaromyces thermophilus (Chu et al ; Guo et al ) have been reported.…”

Section: High‐temperature Environmentsmentioning

confidence: 99%

Section: High‐temperature Environmentsmentioning

confidence: 99%

Extreme environments: microbiology leading to specialized metabolites

et al. 2019

View full text Add to dashboard Cite

show abstract

“…2 Among distinct types of fungi present in this environment, endophytes are receiving attention due to their ability to produce biologically active natural products. 3,4 Endophytic strains of Talaromyces are still poorly studied, with few works reporting mainly secondary metabolites from the alkaloid, 5 terpene, 6 and polyketide classes. 7 Some of the described compounds possess remarkable pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Polyketides and Other Compounds from Amazonian Endophytic Talaromyces Fungi

Silva

Souza

Bianco

et al. 2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

The continuous search for biologically active compound candidates pushes the pursuit of new substances produced by diverse organisms. Endophytic fungi are known as a promising source of metabolites with several biological activities. Based on the rich Amazonian biodiversity and the chemical potential of microbial sources, three Talaromyces strains, all major endophytes from their respective host plants, were studied aiming at the isolation of biologically active secondary metabolites. Through classical chromatographic approaches, 13 compounds were isolated from the antimicrobial extracts of the studied strains. From these, polyketides, steroids, anhydrides, and phenolic compounds were identified. Among them, two previously undescribed compounds were elucidated based on spectroscopic and spectrometric methods, a homodimer chromanone and a maleic anhydride methyl ester. The antimicrobial activity against a panel of pathogenic microorganisms from extracts, fractions, and isolated compounds was evaluated.

show abstract

“…The antimicrobial activities of 2 and 3 were determined by the agar diffusion assay method 9 Journal of Natural Products NOTE respectively, produced from 50 μg of 3. Compound 2 was much less active than 3.…”

mentioning

confidence: 99%

Arthrobotrisins A–C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora

et al. 2011

Self Cite

View full text Add to dashboard Cite

Arthrobotrys oligospora is a carnivorous fungus that can use mycelia trapping devices to capture their prey. Three novel oligosporons, named arthrobotrisins A-C (1-3), were isolated from A. oligospora and identified by spectroscopic analysis in combination with X-ray diffraction. This is the first time that the relative configuration of naturally occurring oligosporon metabolites has been fully determined. Compound 3 exhibited specific antibacterial activities.

show abstract

Isolation of Putative Biosynthetic Intermediates of Prenylated Indole Alkaloids from a Thermophilic Fungus Talaromyces thermophilus

Cited by 53 publications

References 16 publications

Extreme environments: microbiology leading to specialized metabolites

Extreme environments: microbiology leading to specialized metabolites

Antifungal Polyketides and Other Compounds from Amazonian Endophytic Talaromyces Fungi

Arthrobotrisins A–C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora

Contact Info

Product

Resources

About