Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata

Park, Seon Ju; Nhiệm, Nguyễn Xuân; Lee, Taek Hwan; Kim, Nanyoung; Kim, Sun Yeou; Chae, Han-Jung; Kim, Seung Hyun

doi:10.1016/j.bmcl.2015.08.061

Cited by 11 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The plant extraction and isolation were conducted as previously described [20,47]. In brief, dried leaves of I. dentatum (5.0 kg) were extracted with MeOH (3 × 10 L, 50 °C) and sonicated for 4 h after solvent evaporation, producing 290.0 g extract.…”

Section: Plan Materials Extraction and Isolationmentioning

confidence: 99%

See 1 more Smart Citation

Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells

Ullah

Kwon

Park

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

We investigated whether isoleucilactucin, an active constituent of Ixeridium dentatum, reduces inflammation caused by coal fly ash (CFA) in alveolar macrophages (MH-S). The anti-inflammatory effects of isoleucilactucin were assessed by measuring the concentration of nitric oxide (NO) and the expression of pro-inflammatory mediators in MH-S cells exposed to CFA-induced inflammation. We found that isoleucilactucin reduced CFA-induced NO generation dose-dependently in MH-S cells. Moreover, isoleucilactucin suppressed CFA-activated proinflammatory mediators, including cyclooxygenase-2 (COX2) and inducible NO synthase (iNOS), and the proinflammatory cytokines such as interleukin-(IL)-1β, IL-6, and tumor necrosis factor (TNF-α). The inhibiting properties of isoleucilactucin on the nuclear translocation of phosphorylated nuclear factor-kappa B (p-NF-κB) were observed. The effects of isoleucilactucin on the NF-κB and mitogen-activated protein kinase (MAPK) pathways were also measured in CFA-stimulated MH-S cells. These results indicate that isoleucilactucin suppressed CFA-stimulated inflammation in MH-S cells by inhibiting the NF-κB and MAPK pathways, which suggest it might exert anti-inflammatory properties in the lung.

show abstract

Section: Plan Materials Extraction and Isolationmentioning

confidence: 99%

“…The plant extraction and isolation were conducted as previously described [20,47]. In brief, dried leaves of I. dentatum…”

Section: Plan Materials Extraction and Isolationmentioning

confidence: 99%

Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells

Ullah

Kwon

Park

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Among them, compounds were identified based on the combination of accurate mass, UV spectrum and retention time (Table 2). Thirteen compounds isolated in our previous study were used as standard compounds to confirm the identification of the observed peaks in TCC [10]. Peaks for these thirteen compounds (peaks 5, 6, 8, 9, 11, 12, 15, 19, 21, 22, 25, 28, 29) were found in TCC.…”

Section: Resultsmentioning

confidence: 91%

“…Regarding the chemical constituents, aliphatic compounds, triterpenoids, and sesquiterpene glycosides have been reported from I. dentata [6][7][8]. In our previous studies, we reported that I. dentata has anti-inflammatory activity and increase amylase synthesis and secretion and suggested sesquiterpene glycosides as active components [9][10].…”

Section: Introductionmentioning

confidence: 93%

Chemical Profiling of the Aerial Parts and Roots of Ixeris dentata Using LCQTOF-MS Combined with Multivariate Chemometric Analysis

Jh¹,

Park²,

G³

et al. 2017

Herb Med

View full text Add to dashboard Cite

Ixeris dentata (Thunb. ex Thunb.) Nakai (Asteraceae) is a perennial herb distributed throughout East Asia including Korea, China and Japan. Both its aerial parts and roots are edible as a bitter appetizing vegetable. In addition, they have been used in folk medicine for the treatment of various diseases. In the present study, the chemical profiles of the aerial parts and roots of I. dentata were investigated using HPLC-QTOF-MS combined with multivariate chemometric analysis. From 18 samples collected in 7 different areas, 30 compounds were characterized and most of them were sesquiterpenes and flavonoids. Principal component analysis of them clearly distinguished the samples of I. dentata by the parts, aerial parts and roots. The loading plots gave the information about the important compounds responsible for the discrimination between plant parts. Hierarchical cluster analysis also showed clear distinction between two parts. Although I. dentata samples derived from the same plant, there was difference in their chemical profiles, which might account for their different uses.

show abstract

“…Furthermore, it has been reported that the IDN water extract possesses an anti-inflammatory activity against 2,4-dinitrofluorobenzene- induced atopic dermatitis-like skin inflammation ( 16 ). Previous studies demonstrated that several biologically active compounds including sesquiterpene lactones and flavonoids isolated from Ixeris dentate possesses multiple pharmacological activities on cancer ( 9 17 ), acylcoenzyme A: cholesterol acyltransferase (ACAT) activity ( 9 ), and inflammation ( 13 18 19 ). While the anti-inflammatory activities of IDN and its bio-active compounds have been reported previously, the effect of IDN on the production of pro-inflammatory mediators including PGE 2 and NO has not yet been fully studied.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ixeris dentata Nakai Extract on Nitric Oxide Production and Prostaglandin E₂ Generation in LPS-stimulated RAW264.7 Cells

et al. 2015

View full text Add to dashboard Cite

Inflammation is the basis of severe acute and chronic diseases. This study investigated the anti-inflammatory property of a crude methanol extract (MeOH-ex) and the solvent fractions of Ixeris dentata Nakai (IDN) in LPS-stimulated murine macrophage-like cell line RAW264.7. Here, we showed that the ethyl acetate fraction (EtOAc-fr) had the most potent inhibitory activity on LPS-induced nitric oxide (NO) production among the tested samples, i.e., IDN MeOH-ex and the three different solvent fractions (chloroform, n-hexane, and EtOAc). We further found that the EtOAc-fr significantly inhibited LPS-induced prostaglandin PGE2 (PGE2) generation in RAW264.7 cells. Furthermore, the treatment with EtOAc-fr effectively suppressed the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). These results suggest that the EtOAc-fr of IDN MeOH-ex exhibits an anti-inflammatory activity in vitro by inhibiting LPS-induced NO production and PGE2 generation via suppression of iNOS and COX-2 expression.

show abstract

Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata

Cited by 11 publications

References 29 publications

Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells

Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells

Chemical Profiling of the Aerial Parts and Roots of Ixeris dentata Using LCQTOF-MS Combined with Multivariate Chemometric Analysis

Effect of Ixeris dentata Nakai Extract on Nitric Oxide Production and Prostaglandin E₂ Generation in LPS-stimulated RAW264.7 Cells

Contact Info

Product

Resources

About

Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata

Cited by 11 publications

References 29 publications

Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells

Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells

Chemical Profiling of the Aerial Parts and Roots of Ixeris dentata Using LCQTOF-MS Combined with Multivariate Chemometric Analysis

Effect of Ixeris dentata Nakai Extract on Nitric Oxide Production and Prostaglandin E2 Generation in LPS-stimulated RAW264.7 Cells

Contact Info

Product

Resources

About

Effect of Ixeris dentata Nakai Extract on Nitric Oxide Production and Prostaglandin E₂ Generation in LPS-stimulated RAW264.7 Cells