Isolation, partial characterisation and immunomodulatory activities of polysaccharide from <i>Morchella esculenta</i>

Cui, Hua-Li; Chen, Yan; Wang, Shusheng; Kai, Guiqing; Fang, Yu-Ming

doi:10.1002/jsfa.4436

Cited by 60 publications

(33 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aerosol level was 60%, drift tube temperature was 120°C and column temperature was 40°C. The dextran standards were used to create a calibration curve as previously described [21]. …”

Section: Methodsmentioning

confidence: 99%

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes

Wang

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

This study evaluated the effects of Inonotus obliquus polysaccharides (IOs) on diabetes and other underlying mechanisms related to inflammatory factors and oxidative stress in a mouse model of streptozotocin (STZ)-induced diabetes. Four weeks administration of metformin (120 mg/kg) and IO1-4 (50%-80% alcohol precipitation), or IO5 (total 80% alcohol precipitation) at doses of 50 mg/kg reverses the abnormal changes of bodyweights and fasting blood glucose levels of diabetic mice. IOs significantly increased the insulin and pyruvate kinase levels in serum, and improved the synthesis of glycogen, especially for IO5. IOs restored the disturbed serum levels of superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde. The down-regulation of interleukin-2 receptor, matrix metalloproteinase-9, and the enhancement of interleukin-2 in serum of diabetic mice were significantly attenuated by IOs. Histologic and morphology examinations showed that IOs repaired the damage on kidney tissues, inhibited inflammatory infiltrate and extracellular matrix deposit injuries in diabetic mice. Compared with untreated diabetic mice, IOs decreased the expression of phosphor-NF-κB in the kidneys. These results show that IOs treatment attenuated diabetic and renal injure in STZ-induced diabetic mice, possibly through the modulation of oxidative stress and inflammatory factors. These results provide valuable evidences to support the use of I. obliquus as a hypoglycemic functional food and/or medicine.

show abstract

“…Aerosol level was 60%, drift tube temperature was 120°C and column temperature was 40°C. The dextran standards were used to create a calibration curve as previously described [21]. …”

Section: Methodsmentioning

confidence: 99%

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes

Wang

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…30 mg of PSAN and PSAA were respectively hydrolyzed with 2 mol/L H 2 SO 4 (5 mL) for 8 h at 110 • C in sealed glass tubes [12]. After removal of the residual acid with BaCO 3 , the hydrolysates were analyzed by the evaporative light-scattering detector (ELSD, Waters 2420) system.…”

Section: Analysis Of Monosaccharide Compositionmentioning

confidence: 99%

Characterization and in vitro antitumor activity of polysaccharides from the mycelium of Sarcodon aspratus

Chen

Wang

et al. 2013

International Journal of Biological Macromolecules

Self Cite

View full text Add to dashboard Cite

“…Although free and protein‐bound polysaccharides from mushrooms have been shown to possess important medicinal properties, there is little information in the literature about their biological and physicochemical properties 10, 11. There are some reports on the production of free and protein‐bound polysaccharides from basidiomycete strains such as C. versicolor, Pleurotus ostreatus, Lentinula edodes and Ganoderma lucidum 2, 12, 13.…”

Section: Introductionmentioning

confidence: 99%

Production, purification and characterisation of polysaccharides from Pleurotus ostreatus with antitumour activity

et al. 2012

View full text Add to dashboard Cite

show abstract

Isolation, partial characterisation and immunomodulatory activities of polysaccharide from Morchella esculenta

Abstract: These bioactivity tests showed that the polysaccharides from Morchella esculenta presented significant immune modulating activity, and this finding may offer the basis for the popular use of polysaccharides in functional foods or medicine.

Cited by 60 publications

References 29 publications

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes

Characterization and in vitro antitumor activity of polysaccharides from the mycelium of Sarcodon aspratus

Production, purification and characterisation of polysaccharides from Pleurotus ostreatus with antitumour activity

Contact Info

Product

Resources

About