Isolation, purification and characterization of antioxidative steroid derivative from methanolic extract of Carissa carandas (L.) leaves

Bhadane, Bhushan S.; Patil, Ravindra H.

doi:10.1016/j.bcab.2017.03.012

Cited by 16 publications

(10 citation statements)

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“…The stigmasterol from Carissa carandas was reported for marked anti-inflammatory activity (Galipalli et al, 2015). Recently, Bhadane and Patil (2017) (Dewick, 2002;Figure 6). They have been studied for potential bioactivities in some members of family Apocynaceae (Bhaskar & Balakrishnan, 2015).…”

Section: Sterolsmentioning

confidence: 97%

“…The stigmasterol from Carissa carandas was reported for marked anti‐inflammatory activity (Galipalli et al, ). Recently, Bhadane and Patil () investigated antioxidative and anti‐inflammatory potential of methanolic extracts of Carissa carandas leaves by activity‐guided fractionation and 20‐hydroxypreganan‐18‐oic acid (121) was reported as a potential antioxidative and anti‐inflammatory steroid with t EC 50 values 546.4 and 498.5 μg/ml, respectively, for DPPH and OH − radical scavenging activities.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Qualitative and quantitative DPPH scavenging assays were studied to determine the antioxidative potential of Tabernaemontana divaricata leaves extract (Rumzhum, Rahman, & Kazal, ). Recently, Bhadane and Patil () evaluated antioxidant activity of methanolic leaves extract and column eluted steroidal fraction of Carissa carandas by TLC bioautography method. The results indicated a yellow colored DPPH radical scavenging band by the antioxidant compound on TLC plates against the purple background.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…Among them, scopoletin and carissone showed significant inhibition of NO with IC 50 24.6 and 20.1 μg/ml, respectively. Recently, in vitro anti‐inflammatory activity of steroidal derivative from Carissa carandas leaves was studied by erythrocyte membrane stabilizing potential and the activity was found comparable to diclofenac sodium at 3.5 mg/ml (Bhadane & Patil, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…Qualitative and quantitative DPPH scavenging assays were studied to determine the antioxidative potential of Tabernaemontana divaricata leaves extract (Rumzhum, Rahman, & Kazal, 2012). Recently, Bhadane and Patil (2017) Alstonia scholaris flower extract, and the reported activity was found higher than fruit extract. Further, significant DNA damage inhibition and antioxidative potential of Carissa carandas were studied by Verma, Shrivastava, and Kumar (2015).…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

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Section: Sterolsmentioning

confidence: 97%

Section: Phytochemistrymentioning

confidence: 99%

Section: Pharmacological Propertiesmentioning

confidence: 99%

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…Qualitative and quantitative DPPH scavenging assays were studied to determine the antioxidative potential of Tabernaemontana divaricata leaves extract (Rumzhum, Rahman, & Kazal, 2012). Recently, Bhadane and Patil (2017) Alstonia scholaris flower extract, and the reported activity was found higher than fruit extract. Further, significant DNA damage inhibition and antioxidative potential of Carissa carandas were studied by Verma, Shrivastava, and Kumar (2015).…”

Section: Antioxidant Activitymentioning

confidence: 99%

See 3 more Smart Citations