2019
DOI: 10.1016/j.phymed.2019.153010
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Isolation, synthesis, and drug interaction potential of secondary metabolites derived from the leaves of miracle tree (Moringa oleifera) against CYP3A4 and CYP2D6 isozymes

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Cited by 18 publications
(14 citation statements)
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“…13 Prior studies reported the isolation of compound 1 from the methanol extract of M. oleifera [21,22]. In agreement with other research groups, we isolated this compound from the methanol extract of M. oleifera (#18332) in the previous isolation work [23]. However, compound 1 in the plant sample (#18332) and 13 herbal supplements in this analytical work were undetectable.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…13 Prior studies reported the isolation of compound 1 from the methanol extract of M. oleifera [21,22]. In agreement with other research groups, we isolated this compound from the methanol extract of M. oleifera (#18332) in the previous isolation work [23]. However, compound 1 in the plant sample (#18332) and 13 herbal supplements in this analytical work were undetectable.…”
Section: Discussionsupporting
confidence: 87%
“…Secondary metabolites (1-5 and 7-9) were previously isolated and elucidated from the authenticated plant material #18332 at the National Center for Natural Products Research (NCNPR). Based on 1 H NMR data and HPLC chromatograms, the purity of phytoconstituents 2-5 and 7-9 was approximately 90-95 % while the purity for compound 1 was 85 % [23]. Compound 6 was purchased from Sigma-Aldrich with 85 % purity.…”
Section: Chemicals and Plant Samplesmentioning
confidence: 99%
“…Many drug–herb interactions are thought to result from the inhibitory effect on these CYP enzymes blocking the activation of cyclophosphamide [ 61 ]. Indeed, moringa extracts have been shown to inhibit liver CYP isozymes including CYP1A2 [ 62 ], CYP3A4 and CYP2D6 [ 63 ]. However, CYP enzymes constitute a superfamily of more than 50 isoforms responsible for both activating and detoxifying drugs.…”
Section: Discussionmentioning
confidence: 99%
“…The consumption of these herbs may potentiate or antagonise the effects of some antihypertensive drugs, causing changes to the pharmacokinetics of the drug, primarily their metabolic activities [40]. Certain bioactive compounds and aqueous extracts of M. oleifera were determined to have CYP3A4 and CYP1A2 inhibitory properties respectively [41,42]. Hence, certain antihypertensive drugs such as amlodipine, is metabolised by CYP3A4 [43].…”
Section: Plos Onementioning
confidence: 99%