Isoliquiritigenin and -sitosterol from Cissus polyantha Tuber Glig and Brandt

Sani, Yahaya Muhammad; Musa, Abdullahi; Tajuddeen, Nasir; Abdullahi, S.M.; Abdullahi, M. I.; Pateh, U. U.; Idris, Abdullahi

doi:10.5897/jmpr2015.5786

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…Thus, the spectroscopic data of compound 4 suggest the presence of two sterols, according to the reported spectra in the literature for βsitosterol and stigmasterol 22 . β-sitosterol and stigmasterol were previously isolated from the hexane extract of stems of C. quadrangularis 13 and also from methanolic and ethyl acetate extracts of aerial parts and roots of C. assamica 23 , C. polyantha 24 , C. rheoifolia and C. pteroclada 25,26 . β-sitosterol is the principal sterol in plant materials, in addition to its 22-dehydro analogue stigmasterol, they occur in most plants playing roles in the regulation of membrane fluidity, and cellular developmental processes acting as precursors of the brassinosteroids; a class of plant hormones 27 .…”

Section: Resultsmentioning

confidence: 99%

“…The 13 C NMR data suggests the structure of a carboxylic acid with the molecular formula of C28H56O2, which corresponds with the octacosanoic acid. The signals were assigned; accordingly, at δ 178.47 a signal that corresponds to a carboxylic carbon at C1, along with the signals at 33.79 (C2) of the alpha carbonyl methylene, and 31.94 (C26), 29.69 (C4 to C25), 24.72 (C23), 22.70 (C27) and 14.12 (C1). This is the first report of the presence of octacosanoic acid in a plant from the genus of Cissus, although is one of the most common plant wax fatty acids 20,21 .…”

Section: Resultsmentioning

confidence: 99%

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Lipid constituents fromCissus trifoliatastems

Méndez-López,

González Llerena,

Espinosa-Rodríguez

et al. 2023

Preprint

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ObjectiveThe stems from plants of the genusCissusare used in traditional medicine worldwide. In MexicoCissus trifoliatais employed for the management of several diseases, however little is known about the active compounds. The present investigation focuses on the extraction, isolation, and characterization of the lipid contents from the stems ofC. trifoliataby chromatographic, spectroscopic, and spectrometric techniques.MethodsThe hexane extract was fractionated sequentially with hexane and ethanol and visualized by TLC. The compounds were isolated by column chromatography and structurally elucidated using NMR. In addition, the complete extract and solids obtained by fractionations were analyzed by GC-MS.ResultsAccording to NMR signals, solids present in the hexane extract correspond to hentriacontane, octatetracontane, octacosanoic acid, tricosyl tetracosanoate and sitosterol. Furthermore, the analysis by GC-MS found 33 compounds, and the most abundant were hentriacontane, squalene, palmitic acid, oleic acid, β-sitosterol, and nonacosane.ConclusionThis report describes the major constituents in the hexane extract fromCissus trifoliatastems. Our analysis suggests an abundant composition of higher alkanes, fatty acids, and sterols, which are the major lipid components of cuticular waxes and plant cell membranes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Lipid constituents fromCissus trifoliatastems

Méndez-López,

González Llerena,

Espinosa-Rodríguez

et al. 2023

Preprint

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“…In the case of eicosanoic acid, was also a major constituent of hexane extract of roots in C. quadrangularis 52 . Regarding sterols, βsitosterol and stigmasterol were previously isolated from the hexane extract of stems of C. quadrangularis 52 and the methanolic and ethyl acetate extracts of the aerial parts and roots of C. assamica 55 , C. polyantha 56 , C. rheoifolia 57,58 and C. pteroclada 58 . Campesterol was isolated from hexane 52 and ethanolic extract of C. quadrangularis stems 59 and is also found in the methanolic extract of the roots of C. rheifolia 57 .…”

Section: Cissus Trifoliata Compounds and Their Role In Plant Physiologymentioning

confidence: 99%

Phytochemistry<em> </em>and biological activities of <em>Cissus trifoliata</em> against carcinomas

Méndez-López

2024

Preprint

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There is an urgent need to develop new therapies for cancer treatment due to high rates of resistance and tumor relapse. Moreover, chemotherapy and radiation weaken the immune system and leave patients susceptible to sudden death from infections and organ failure since antineoplastic drugs lack specificity. Hence, scientists worldwide continue the search for natural alternatives with anticancer activities and fewer side effects. In this regard, traditional medicine offers strategies for preventing and treating numerous diseases and nowadays scientific studies worldwide highlight some of the mechanisms underlying their potential as an effective alternative for the management of cancer. In Mexico, Mayan healers have been prescribed mainly medicinal plants for more than 2,000 years. Furthermore, their ethnomedical knowledge has led to drug discovery or the development of herbal remedies. Medicinal plants from the genus of Cissus remain an important element of all indigenous medical systems in Mexico including the Mayan tribes in Yucatan, particularly for the management of gastrointestinal illnesses, sores, cutaneous diseases, and tumors. In this review, we present the reported bioactivities against cancer cells of the extract and compounds from the species of Cissus with a particular focus on recent studies on the phytochemistry of C. trifoliata which is widely distributed in Mexican territory and used for tumor management in traditional medicine.

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“…This steroid is ubiquitous in the plant Kingdom. In the genus Cissus, it has been found in C. polyantha (Sani et al, 2015), C. quadrangularis (Singh et al, 2007) and C. trifoliata Méndez-López et al, 2020).…”

Section: Chemical Investigationmentioning

confidence: 99%

Phytochemicals with ?-glucosidase inhibitory activity from cissus javana, dendrobium christyanum, gastrochilus bellinus and huberantha jenkinsii

San

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Phytochemical investigations of Cissus javana DC., Dendrobium christyanum Rchb. f., Gastrochilus bellinus Rchb. f. Kuntze and Huberantha jenkinsii (Hook. f. & Thomson) Chaowasku led to the isolation of twenty-seven compounds, six of which were new naturally occurring compounds. From Cissus javana, three known compounds were isolated, including bergenin, stigmast-4-en-3-one, and ?-sitosterol. From Dendrobium christyanum, thirteen known compounds were identified, namely, n-eicosyl trans-ferulate, n-docosyl 4-hydroxy-trans-cinnamate, 4,5-dihydroxy-2-methoxy-9,10-dihydrophenanthrene, moscatilin, aloifol I, gigantol, batatasin III, dendrosinen B, coniferyl aldehyde, methyl haematommate, atraric acid, vanillin and diorcinolic acid. From Gastrochilus bellinus, four new compounds, comprising three phenanthropyrans and a phenanthrene derivative, were isolated and structurally characterized. From Huberantha jenkinsii, two new alkaloids of 8-oxoprotoberberine type were isolated along with five known compounds including mangiferin, allantoin, oxylopinine,�N-trans-feruloyl tyramine and N-trans-p-coumaroyl tyramine. The structures of these compounds were determined by UV, IR, MS and NMR spectroscopic methods, and comparison of the data with literature values. Methyl haematommate (IC50 18.7 ? 2.1 ?M), n-docosyl 4-hydroxy-trans-cinnamate (IC50 4.6 ? 0.2 ?M), N-trans-feruloyl tyramine (IC50 30.6 ? 2.9 ?M) and N-trans-p-coumaroyl tyramine (IC50�0.6 ? 0.1 ?M) showed potent ?-glucosidase inhibitory activity in comparison with the drug acarbose (IC50 724.7 ? 46 ?M). N-Docosyl 4-hydroxy-trans-cinnamate at 0.212 mM also displayed 31.6 ? 4.4 %. enhancement of glucose uptake in L6 cells. Mangiferin showed moderate ?-glucosidase inhibition (IC50 253.6 ? 14.2 ?M) and recognizable cellular glucose uptake stimulatory activity (208.1 ? 10.7% enhancement at a concentration of 0.237 mM) as compared with insulin (146.6 ? 35.8 % at a concentration of 500 nM).

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Isoliquiritigenin and -sitosterol from Cissus polyantha Tuber Glig and Brandt

Cited by 6 publications

References 7 publications

Lipid constituents fromCissus trifoliatastems

Lipid constituents fromCissus trifoliatastems

Phytochemistry<em> </em>and biological activities of <em>Cissus trifoliata</em> against carcinomas

Phytochemicals with ?-glucosidase inhibitory activity from cissus javana, dendrobium christyanum, gastrochilus bellinus and huberantha jenkinsii

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