Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice

Singh, D. P.; Singh, Jasmeet; Boparai, Ravneet K.; Zhu, Jianhua; Mantri, Shrikant; Khare, Pragyanshu; Khardori, Romesh; Kondepudi, Kanthi Kiran; Chopra, Kanwaljit; Bishnoi, Mahendra

doi:10.1016/j.phrs.2017.06.015

Cited by 110 publications

(82 citation statements)

References 33 publications

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“…Further, it has been described an increase in the relative abundance of Akkermansia spp. population in HFD‐fed mice treated with protective natural compounds . In this regard, a positive modulatory effect of quercetin on Akkermansia genus has already been shown in our A model justifying its possible protective role in dHFDQ .…”

Section: Discussionsupporting

confidence: 62%

Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice

Porras

Nistal

Martínez‐Flórez

et al. 2019

Molecular Nutrition Food Res

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Scope Modulation of intestinal microbiota has emerged as a new therapeutic approach for non‐alcoholic fatty liver disease (NAFLD). Herein, it is addressed whether gut microbiota modulation by quercetin and intestinal microbiota transplantation can influence NAFLD development. Methods and results Gut microbiota donor mice are selected according to their response to high‐fat diet (HFD) and quercetin in terms of obesity and NAFLD‐related biomarkers. Germ‐free recipients displayed metabolic phenotypic differences derived from interactions between microbiota transplanted, diets, and quercetin. Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD‐non‐responder donor and the HFD‐fed donor with the highest response to quercetin results in a protective phenotype against HFD‐induced NAFLD, in a mechanism that involves gut–liver axis alteration blockage in these receivers. Gut microbiota from the HFD‐responder donor predisposed transplanted germ‐free mice to NAFLD. Divergent protective and deleterious metabolic phenotypes exhibited are related to definite microbial profiles in recipients, highlighting the predominant role of Akkermansia genus in the protection from obesity‐associated NAFLD development. Conclusions The results provide scientific support for the prebiotic capacity of quercetin and the transfer of established metabolic profiles through gut microbiota transplantation as a protective strategy against the development of obesity‐related NAFLD.

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Section: Discussionsupporting

confidence: 62%

Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice

Porras

Nistal

Martínez‐Flórez

et al. 2019

Molecular Nutrition Food Res

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show abstract

“…; Singh et al . 2017b). Further TNF‐ α via TLR‐4 and NF κβ signalling has been associated with the downregulation of tight junction proteins, Claudin‐5 and ZO‐2, that are the major cell adhesion molecules of the BBB (Braniste et al .…”

Section: Discussionmentioning

confidence: 99%

“…Selected primers for these experiments were taken from our previously published studies (Singh et al . ,b). qPCR conditions were set as follows: 95°C for 10 min, followed by 45 cycles of 95 and 60°C for 1 min.…”

Section: Methodsmentioning

confidence: 99%

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Lactobacillus plantarumMTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation-induced behaviour, biochemical and selected gut microbial aberrations in mice

Dhaliwal

Singh

et al. 2018

J Appl Microbiol

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“…Many publications reported that dietary tea polyphenols, at different doses, attenuated body weight gain and decreased the ratio of Firmicutes to Bacteroidetes in mice fed an HFD . It is unclear, however, whether the results were due to the prevention of HFD‐induced changes in microbiota by tea polyphenol treatment, and the role of intestinal microbiota in mediating the beneficial effects of tea, remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Green Tea Polyphenols Modify the Gut Microbiome in db/db Mice as Co‐Abundance Groups Correlating with the Blood Glucose Lowering Effect

Chen

Liu

Sun

et al. 2019

Molecular Nutrition Food Res

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Scope The effects of green tea polyphenols, Polyphenon E (PPE), and black tea polyphenols, theaflavins (TFs), on gut microbiota and development of diabetes in db/db mice are investigated and compared. Methods and results Supplementation of PPE (0.1%) in the diet of female db/db mice for 7 weeks decreases fasting blood glucose levels and mesenteric fat while increasing the serum level of insulin, possibly through protection against β‐cell damage. However, TFs are less or not effective. Microbiome analysis through 16S rRNA gene sequencing shows that PPE and TFs treatments significantly alter the bacterial community structure in the cecum and colon, but not in the ileum. The key bacterial phylotypes responding to the treatments are then clustered into 11 co‐abundance groups (CAGs). CAGs 6 and 7, significantly increased by PPE but not by TFs, are negatively associated with blood glucose levels. The operational taxonomic units in these CAGs are from two different phyla, Firmicutes and Bacteroidetes. CAG 10, decreased by PPE and TFs, is positively associated with blood glucose levels. Conclusion Gut microbiota respond to tea polyphenol treatments as CAGs instead of taxa. Some of the CAGs associated with the blood glucose lowering effect are enriched by PPE, but not TFs.

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Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice

Cited by 110 publications

References 33 publications

Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice

Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice

Lactobacillus plantarumMTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation-induced behaviour, biochemical and selected gut microbial aberrations in mice

Green Tea Polyphenols Modify the Gut Microbiome in db/db Mice as Co‐Abundance Groups Correlating with the Blood Glucose Lowering Effect

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