Isoniazid Completion Rates for Latent Tuberculosis Infection Among College Students Managed by a Community Pharmacist

Hess, Karl; Goad, Jeffery A.; Wu, Joanne; Johnson, Kathleen A.

doi:10.3200/jach.57.5.553-556

Cited by 21 publications

(33 citation statements)

References 15 publications

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“…Of our patients 81% with latent TBI who initiated INH chemoprophylaxis therapy; 69% and 79% of these patients completed 9 months and 6 months of IPT, respectively. The percentage of INH completion at 9 months in this study was comparable to the 62% and 59% completion rate from Kwara et al 27 and Hess et al, 29 respectively. In addition, the 6-month completion rate from our study was comparable to other studies, 30,31 but was higher compared to the study conducted by Kwara et al 27 We also found that patients with CD4 > 200 cells/lL had better adherence to IPT.…”

Section: Discussionsupporting

confidence: 89%

Feasibility and Efficacy of Isoniazid Prophylaxis for Latent Tuberculosis in HIV-Infected Clients Patients in Thailand

Khongphatthanayothin

Avihingsanon²,

Teeratakulpisarn³

et al. 2012

AIDS Research and Human Retroviruses

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A prospective study was conducted in 4339 HIV-positive clients at the Thai Red Cross AIDS Research Centre (TRC-ARC) Anonymous clinic, Bangkok, Thailand between January 2003 and April 2008. A tuberculin skin test (TST) was done for all patients without a previous history of tuberculosis (TB). Nine months of isoniazid (INH) was given for all positive TST/no active TB. TST-negative clients were asked to repeat the TST annually. The study aim was to evaluate the feasibility and efficacy of INH prophylaxis for preventing TB in HIV-positive Thai patients. Of those patients, 4111 (94.7%) had a TST done; 1157 (28.1%) were TST positive and 799 patients started INH prophylaxis. In all, 551 (69%) and 633 (79.2%) patients completed 9 months and 6 months of INH, respectively; 176 (20.2%) patients had a negative TST at baseline and subsequently converted to positive. Only patients with a baseline CD4 >200 cells/μL (p=0.000) and currently on antiretroviral (ARV) treatment (p=0.000) were related to having a positive TST. This baseline CD4 level was also significantly related to higher INH completion rates at 6 months (p=0.000). Interestingly, none of INH completion patients developed active TB. The feasibility of INH prophylaxis in TST-positive patients in this setting is possible. However, the long-term advantage of INH prophylaxis in terms of TB prevention, especially in HIV-1-infected patients on highly active antiretroviral therapy (HAART), is still an issue that needs more research.

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Section: Discussionsupporting

confidence: 89%

Feasibility and Efficacy of Isoniazid Prophylaxis for Latent Tuberculosis in HIV-Infected Clients Patients in Thailand

Khongphatthanayothin

Avihingsanon²,

Teeratakulpisarn³

et al. 2012

AIDS Research and Human Retroviruses

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“…Other studies reported higher rates of treatment failure associated with side effects. 8,25 This could be a limitation of our sample size or a result of comparing the 3 LTBI regimens, 1 of which is relatively new. This does highlight that providers may want to consider more than just the side effect profile when deciding on an LTBI regimen for patients.…”

Section: Discussionmentioning

confidence: 99%

“…8 The most participants were lost to follow-up in the isoniazidonly regimen, which is the longest regimen of the 3 included in this analysis. This finding argues for careful screening and education before initiating therapy and during treatment in order to enhance the likelihood of follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Factors That Influence Treatment Completion for Latent Tuberculosis Infection

et al. 2017

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Introduction:The aim of this study is to describe factors associated with noncompletion of latent tuberculosis infection (LTBI) therapy.Methods: We conducted a retrospective cohort study of adults who initiated LTBI treatment with isoniazid, rifampin, or isoniazid-rifapentine at 5 clinics. Demographic, treatment, and monitoring characteristics were abstracted. We estimated descriptive statistics and compared differences between completers and noncompleters using t tests and 2 tests. Results: The rate of completion across LTBI regimens was 66% (n ‫؍‬ 393). A greater proportion of noncompleters were unmarried, used tobacco and/or alcohol, and had more medical problems than completers (all P < .05). A larger proportion of noncompleters received charity care compared with completers (P < .001). The most common reason for treatment discontinuation was loss to follow-up; the majority of these participants were treated with the longest isoniazid-only regimen.Conclusions: Patients at risk of progression to active tuberculosis with factors associated with noncompletion may benefit from interventions that enhance adherence to LTBI therapy. These interventions could include enhanced outreach, incentive programs, or home visits. (J Am Board Fam Med 2017;30: 520 -527.)

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“…6,7 However, the treatment dropout rate is high, with completion rates of between 45% and 67%. [8][9][10] Although Norway is a small country, treatment for…”

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confidence: 99%

Management of latent tuberculous infection in Norway in 2009: a descriptive cross-sectional study

Olsen

Andersen

Aßmus

et al. 2013

public health action

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Isoniazid Completion Rates for Latent Tuberculosis Infection Among College Students Managed by a Community Pharmacist

Abstract: LTBI clinics are a unique niche for community pharmacies and can provide individualized patient care to ensure LTBI treatment adherence, monitoring for disease progression, and safety of INH.

Cited by 21 publications

References 15 publications

Feasibility and Efficacy of Isoniazid Prophylaxis for Latent Tuberculosis in HIV-Infected Clients Patients in Thailand

Feasibility and Efficacy of Isoniazid Prophylaxis for Latent Tuberculosis in HIV-Infected Clients Patients in Thailand

Factors That Influence Treatment Completion for Latent Tuberculosis Infection

Management of latent tuberculous infection in Norway in 2009: a descriptive cross-sectional study

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