Isoprinosine Does not Influence the Natural History of Herpes Zoster or Postherpetic Neuralgia

Cm, Payne; Ap, Menday; Rogers, Thomas R.; Rc, Staughton

doi:10.3109/00365548909035675

Cited by 7 publications

(1 citation statement)

References 10 publications

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“…Table 1 summarizes the characteristics of the 39 studies that met the inclusion criteria. The pharmacological and non-pharmacological strategies used to prevent PHN consisted of antiviral agents (AV) [ 83 - 109 ]; a combination of antiviral agents and antiepileptics (AV + AE) [ 93 , 98 - 101 , 104 , 107 - 109 ]; electric nerve stimulation (ENS) [ 93 , 103 ]; a combination of antiviral agents and electric nerve stimulation (AV-ENS) [ 103 ]; a combination of antiviral agents, antiepileptics, and paravertebral block using local anesthetics and steroids (AV + AE-pv) [ 97 , 102 ]; a combination of antiviral agents and epidural block using local anesthetics and steroids (AV-eLS) [ 96 ]; a combination of antiviral agents and steroids (AV + SR) [ 88 , 110 , 111 ]; continuous epidural block using local anesthetics, steroids and epinepherine (EPI-LSE) [ 110 ]; steroids (SR) [ 92 , 112 - 115 ]; antiepileptics (AE) [ 92 , 93 , 115 ]; a combination of antiviral agents and intracutaneous injection using local anesthetics and steroids (AV + iLS) [ 105 ]; a combination of antiviral agents and subcutaneous injection using local anesthetics and steroids (AV + sLS) [ 106 ]; varicella zoster vaccine immunoglobulin (VZVIG) [ 116 ]; adrenocorticotropic hormone (ACTH) [ 112 ]; a combination of antivial agents and intracutaneous injection using methylene blue and local anesthetics (AV-iLM) [ 117 ]; a combination of antiviral...…”

Section: Resultsmentioning

confidence: 99%

Pharmacological and non-pharmacological strategies for preventing postherpetic neuralgia: a systematic review and network meta-analysis

Kim

Choi

et al. 2021

Korean J Pain

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Background Postherpetic neuralgia (PHN) is a refractory complication of herpes zoster (HZ). To prevent PHN, various strategies have been aggressively adopted. However, the efficacy of these strategies remains controversial. Therefore, we aimed to estimate the relative efficacy of various strategies used in clinical practice for preventing PHN using a network meta-analysis (NMA). Methods We performed a systematic and comprehensive search to identify all randomized controlled trials. The primary outcome was the incidence of PHN at 3 months after acute HZ. We performed both frequentist and Bayesian NMA and used the surface under the cumulative ranking curve (SUCRA) values to rank the interventions evaluated. Results In total, 39 studies were included in the systematic review and NMA. According to the SUCRA value, the incidence of PHN was lower in the order of continuous epidural block with local anesthetics and steroids (EPI-LSE), antiviral agents with subcutaneous injection of local anesthetics and steroids (AV + sLS), antiviral agents with intracutaenous injection of local anesthetics and steroids (AV + iLS) at 3 months after acute HZ. EPI-LSE, AV + sLS and AV + iLS were also effective in preventing PHN at 1 month after acute HZ. And paravertebral block combined with antiviral and antiepileptic agents was effective in preventing PHN at 1, 3, and 6 months. Conclusions The continuous epidural block with local anesthetics and steroid, antiviral agents with intracutaneous or subcutaneous injection of local anesthetics and a steroid, and paravertebral block combined with antiviral and antiepileptic agents are effective in preventing PHN.

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Section: Resultsmentioning

confidence: 99%

Pharmacological and non-pharmacological strategies for preventing postherpetic neuralgia: a systematic review and network meta-analysis

Kim

Choi

et al. 2021

Korean J Pain

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Antiviral treatment for preventing postherpetic neuralgia

Chen

Yang

et al. 2009

Cochrane Database of Systematic Reviews

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Oral acyclovir did not reduce the incidence of PHN significantly. There is insufficient evidence from randomised controlled trials to determine whether other antiviral treatments prevent PHN. Additional well-designed, randomised controlled trials of famciclovir or other new antiviral agents, with a greater number of participants are needed. Future trials should pay more attention to the severity of pain and quality of life of participants, and should be conducted among different subgroups of people, such as people who are immunocompromised.

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Antiviral treatment for preventing postherpetic neuralgia

Chen

Yang

et al. 2014

Cochrane Database of Systematic Reviews

194

117

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There is high quality evidence that oral aciclovir does not reduce the incidence of PHN significantly. In addition, there is insufficient evidence to determine the effect of other antiviral treatments; therefore, further well-designed RCTs are needed to investigate famciclovir or other new antiviral agents in preventing PHN. Future trials should pay more attention to the severity of pain and quality of life of participants, and should be conducted among different subgroups of people, such as people who are immunocompromised.

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Isoprinosine Does not Influence the Natural History of Herpes Zoster or Postherpetic Neuralgia

Cited by 7 publications

References 10 publications

Pharmacological and non-pharmacological strategies for preventing postherpetic neuralgia: a systematic review and network meta-analysis

Pharmacological and non-pharmacological strategies for preventing postherpetic neuralgia: a systematic review and network meta-analysis

Antiviral treatment for preventing postherpetic neuralgia

Antiviral treatment for preventing postherpetic neuralgia

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