Isosteviol sodium attenuates high fat/high cholesterol-induced myocardial dysfunction by regulating the Sirt1/AMPK pathway

Mei, Ying; Hu, Hui; Deng, Liangjun; Sun, Xiaoou; Tan, Wen

doi:10.1016/j.bbrc.2022.06.044

Biochemical and Biophysical Research Communications

2022

DOI: 10.1016/j.bbrc.2022.06.044

|View full text |Cite

Isosteviol sodium attenuates high fat/high cholesterol-induced myocardial dysfunction by regulating the Sirt1/AMPK pathway

Ying Mei

Hui Hu

Liangjun Deng

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Targeting mitochondrial shape: at the heart of cardioprotection

Hernandez-Resendiz,

Prakash,

Loo

et al. 2023

Basic Res Cardiol

View full text Add to dashboard Cite

There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI. As such, therapeutic approaches directed at preserving the morphology and functionality of mitochondria may provide an important strategy for cardioprotection. In this article, we provide an overview of the alterations in mitochondrial morphology which occur in response to acute myocardial IRI, and highlight the emerging therapeutic strategies for targeting mitochondrial shape to preserve mitochondrial function which have the future therapeutic potential to improve health outcomes in patients presenting with AMI.

show abstract

Targeting mitochondrial shape: at the heart of cardioprotection

Hernandez-Resendiz,

Prakash,

Loo

et al. 2023

Basic Res Cardiol

View full text Add to dashboard Cite

show abstract

Attenuation of Cardiomyocyte Hypertrophy Via Inhalation of Isosteviol-Loaded Exosome in Mice

Guo,

Li,

et al. 2024

Pharm Chem J

View full text Add to dashboard Cite

The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

Zhang,

Xu,

Guo

et al. 2024

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Isosteviol sodium attenuates high fat/high cholesterol-induced myocardial dysfunction by regulating the Sirt1/AMPK pathway

Cited by 3 publications

References 37 publications

Targeting mitochondrial shape: at the heart of cardioprotection

Targeting mitochondrial shape: at the heart of cardioprotection

Attenuation of Cardiomyocyte Hypertrophy Via Inhalation of Isosteviol-Loaded Exosome in Mice

The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

Contact Info

Product

Resources

About