Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression

Zhang, Qi; Cao, Wanshuang; Yang, Chenying; Hong, Lixia; Geng, Shanshan; Han, Hongmei; Zhong, Caiyun

doi:10.1016/j.jnutbio.2022.109226

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…(35) An attenuation of immune blockade therapy has been reported in isothiocyanates, which are found in cruciferous vegetables. (36) Combination treatment of isothiocyanates and anti-PD-1 mAb weakened the sensitivity of tumor cells to anti-PD-1 therapy. The mechanism for reducing the effect of immune blockade inhibitors is mediated by TP63 inducing up-regulation of PD-L1 in tumors.…”

Section: Discussionmentioning

confidence: 99%

Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance

Yamamoto,

Tanaka,

Takeda

et al. 2024

J. Clin. Biochem. Nutr.

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Immune checkpoint therapy has been shown to be an effective therapy for many types of tumors. Much attention has been paid to the development of an effector target would be helpful for immune checkpoint therapy. Genistein has been shown to have an anti-tumor effect both in vitro and in vivo . In this study, we examined the effect of genistein on immune checkpoint blockade therapy against B16F1 melanoma tumors. Mice treated with genistein or anti-programmed death (PD)-1 antibody showed a significant decrease in tumor growth. However, treatment with genistein had no effect on or attenuated the efficacy of immune checkpoint therapy. The percentages of T cell receptor (TCR)β + CD4 + and TCRβ + CD8 + cells and the concentrations of interferon-γ and tumor necrosis factor-α in tumor tissue were not different among the experimental groups. A significant difference was also not found in microbe composition. Interestingly, a high expression level of PD-ligand (L)1 closely reflected the outcome of therapy by genistein or anti-PD-1 antibody. The study showed that a combination of genistein treatment does not improve the effect of immune blockade therapy. It also showed that a high PD-L1 expression level in tumors is a good prediction maker for the outcome of tumor therapy.

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Section: Discussionmentioning

confidence: 99%

Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance

Yamamoto,

Tanaka,

Takeda

et al. 2024

J. Clin. Biochem. Nutr.

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“…Unfortunately, the authors did not look further into the combination of SFN and anti‐PD‐1 therapy. In our previous study, it was found that SFN upregulated the expression of PD‐L1 in gastric cancer cells and partially inhibited the effect of anti‐PD‐L1 mab in homologous mouse models (Zhang et al, 2023). Mechanistically, SFN stimulated the expression of TAp63α in gastric cancer cells, and TAp63α further transcriptionally activated the expression of PD‐L1.…”

Section: Phytochemicals Targeting Immune Checkpoint Moleculesmentioning

confidence: 97%

“…Mechanistically, SFN stimulated the expression of TAp63α in gastric cancer cells, and TAp63α further transcriptionally activated the expression of PD‐L1. The upregulated expression of PD‐L1 by SFN did not activate the immune function of mice but weakened the cytotoxicity of CD8 + T cells (Zhang et al, 2023).…”

Section: Phytochemicals Targeting Immune Checkpoint Moleculesmentioning

confidence: 99%

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Phytochemicals in regulating PD‐1/PD‐L1 and immune checkpoint blockade therapy

Zhang,

Yang,

Gao

et al. 2023

Phytotherapy Research

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Clinical treatment and preclinical studies have highlighted the role of immune checkpoint blockade in cancer treatment. Research has been devoted to developing immune checkpoint inhibitors in combination with other drugs to achieve better efficacy or reduce adverse effects. Phytochemicals sourced from vegetables and fruits have demonstrated antiproliferative, proapoptotic, anti‐migratory, and antiangiogenic effects against several cancers. Phytochemicals also modulate the tumor microenvironment such as T cells, regulatory T cells, and cytokines. Recently, several phytochemicals have been reported to modulate immune checkpoint proteins in in vivo or in vitro models. Phytochemicals decreased programmed cell death ligand‐1 expression and synergized programmed cell death receptor 1 (PD‐1) monoclonal antibody to suppress tumor growth. Combined administration of phytochemicals and PD‐1 monoclonal antibody enhanced the tumor growth inhibition as well as CD4+/CD8+ T‐cell infiltration. In this review, we discuss immune checkpoint molecules as potential therapeutic targets of cancers. We further assess the impact of phytochemicals including carotenoids, polyphenols, saponins, and organosulfur compounds on cancer PD‐1/programmed cell death ligand‐1 immune checkpoint molecules and document their combination effects with immune checkpoint inhibitors on various malignancies.

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“…SFN is one of the isothiocyanates whose efficacy in the treatment of GC has been confirmed in vitro and in vivo in nude mice. Its action resulted in the inhibition of cancer cell activity through the induction of PDL-1 expression in diseased cells [109]. The effects of sulforaphane on glycolysis and proliferation of SGC7901 and BGC823 GC cells were also addressed, taking into account the role of the TBX15/KIF2C axis (T-box transcription factor 15/kinesin superfamily member 2C).…”

Section: Wasabimentioning

confidence: 99%

An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer

Kostelecka,

Bryliński,

Komar

et al. 2024

Cancers

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Gastric cancer (GC) ranks third in terms of cancer-related deaths and is the fifth most commonly diagnosed type of cancer. Its risk factors include Helicobacter pylori infection, Epstein–Barr virus infection, the consumption of broiled and charbroiled animal meats, salt-preserved and smoke-enhanced foods, alcohol drinking, tobacco smoking, exposure to ionizing radiation, and positive family history. The limited effectiveness of conventional therapies and the widespread risk factors of GC encourage the search for new methods of treatment and prevention. In the quest for cheap and commonly available medications, numerous studies focus on herbal medicine, traditional brews, and spices. In this review, we outline the potential use of spices, including turmeric, ginger, garlic, black cumin, chili pepper, saffron, black pepper, rosemary, galangal, coriander, wasabi, cinnamon, oregano, cardamom, fenugreek, caraway, clove, dill, thyme, Piper sarmentosum, basil, as well as the compounds they contain, in the prevention and treatment of GC. We present the potential molecular mechanisms responsible for the effectivity of a given seasoning substance and their impact on GC cells. We discuss their potential effects on proliferation, apoptosis, and migration. For most of the spices discussed, we also outline the unavailability and side effects of their use.

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Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression

Cited by 5 publications

References 33 publications

Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance

Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance

Phytochemicals in regulating PD‐1/PD‐L1 and immune checkpoint blockade therapy

An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer

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