Isotope ratio precision with transient sample introduction using ICP orthogonal acceleration time-of-flight mass spectrometry

Abstract

Access and use of this website and the material on it are subject to the Terms and Conditions set forth at Isotope ratio precision with transient sample introduction using ICP orthogonal acceleration time-of-flight mass spectrometry Willie, S. N.; Mester, Z.; Sturgeon, R.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=fr L'accès à ce site Web et l'utilisation de son contenu sont assujettis aux conditions présentées dans le site LISEZ CES CONDITIONS ATTENTIVEMENT AVANT D'UTILISER CE SITE WEB. NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=8899619&lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=8899619&lang=fr READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions? Contact the NRC Publications Archive team atPublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1039/b505309aJournal of Analytical Atomic Spectrometry, 20, 12, pp. 1358Spectrometry, 20, 12, pp. -1364Spectrometry, 20, 12, pp. , 2005 Isotope ratio precision with transient sample introduction using ICP orthogonal acceleration time-of-flight mass spectrometry An assessment of inductively coupled plasma orthogonal acceleration time-of-flight mass spectrometry (ICP-oa-TOF-MS) for measurement of isotope ratios arising from steady-state and transient signal detection is presented. An HPLC pump and autosampler were used to introduce microliter volumes of analyte solution into a carrier flow to generate precise and repeatable transient signals having a FWHM of approximately 1 s. Analog and pseudo pulse data processing modes were evaluated and found to obey Poisson statistics for prediction of isotope ratio performance. Use of pseudo pulse counting is restricted by the limited linear range of response and cannot exceed approximately 0.2 counts per pushout. This limitation does not impede analog detection, which thus permits precise isotope ratio measurements to be achieved at higher analyte concentrations using sho...

Signal correlation in isotope ratio measurements with mass spectrometry: Effects on uncertainty propagation

“…First, tin isotope ratios were measured using ICP-Q-MS, silver isotope ratios using ICP-TOF-MS, and hafnium isotope ratios using MC-ICP-MS. Analysis of various metal standard solutions by ICP-TOF-MS shows that isotopic signal correlation is significant and ranges anywhere between values of cor(x,y) = 0.2 to 0.8 (signal drifts are absent) [23]. The same applies for internal standard methods, i.e.…”

“…The same year Moser et al outlined uncertainty propagation in isotope dilution where a correlation between the isotope ratios was considered [9]. However, these are exceptions to the common error analysis that treats all isotopic intensities as independent variables for error propagation purposes [18][19][20][21][22][23][24]. Since uncertainty propagation has became a popular tool in method validation and measurement traceability evaluations, it is imperative to acknowledge the intricate mathematical aspects of isotopic signal correlations.…”

“…with the measured x/y uncertainty. Such error propagation schemes are common in the literature and they implicitly assume both isotopic signals are independent (uncorrelated) [18][19][20][21][22][23]25]. In other words, while the isotopic intensities themselves are always considered to be highly correlated variables, for the uncertainty analysis they are usually treated as independent random variables.…”

Environmental analysis by inductively coupled plasma mass spectrometry

“…Saturation of the detector should also be avoided. If there is a significant difference in the abundances of the isotopes whose signals are being ratioed, they would indeed not be linearly related to each other over the whole transient signal upon one ENVIRONMENTAL ANALYSIS BY ICP-MS & of them saturating the detector (Willie, Mester, & Sturgeon, 2005). With ICP-TOFMS, when the point-to-point ratio changes over the transient profile in the pulse counting mode, switching to the analog detection mode should provide a constant ratio across the same transient signal (Willie, Mester, & Sturgeon, 2005).…”

O-TOF-ICP-MS analysis of rare earth elements, noble elements, uranium and thorium in river-relating species

“…The analytical characteristics of the TOF-ICP-MS instrument based on axial acceleration have been presented in several reports [21][22][23]. Orthogonal acceleration has been discussed [24][25][26]. The fundamental aspects of the two configurations have been contrasted in several reviews [27,28].…”