Isotryptoquivaline F, a new quinazolinone derivative with anti TNF-α activity from Aspergillus sp. CM9a

Xue, Heng; Xu, Qingyan; Chen, Lu; Shen, Yuemao

doi:10.5582/ddt.2014.01039

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…From another Aspergillus sp. CM9a, an endophytic fungus of Cephalotaxus mannii, Isotryptoquivaline F (61) was isolated and showed good TNF-α antagonistic [89]. Similarly, terrusnolides A-D (62-65), four new butenolides isolated from Aspergillus sp., endophyte of Tripterygium wilfordii exhibited excellent inhibitory effects on the production of interleukin-1β (IL-1β), TNFα, and NO in LPS-induced macrophages [90].…”

Section: Anti-inflammatory Agents Produced By Endophyticmentioning

confidence: 99%

“…endophytic fungus isolated from Alibertia macrophylla led to the isolation of two new eremophilanetype sesquiterpenes, xylarenones F (79) and G (80), together with the two known compounds xylarenones C (81) and D (82), all exhibiting potent anti-inflammatory activity [101]. Recently, eight compounds including two new isochromanone derivatives (3S,4S)-3,8-dihydroxy-6-methoxy-3,4,5trimethylisochroman-1-one (83) and methyl (S)-8-hydroxy-6-methoxy-5-methyl-4a-(3-oxobutan-2-yl)benzoate (84), and six known compounds including (4S)-clearanol C (85) (3R,4S)-3,8-dihydroxy-3-hydroxymethyl-6-meth-oxy-4,5-dimethylisochroman-1-one (86), polygonolide (87), (7S,8S)-8-ethyl-7-hydroxy-2,3,8-trimethyl-5,6,7,8-tetrahydro-4H-chromen-4-one (88), (7R,8S)-8-ethyl-7-hydroxy-2,3,8-trimethyl-5,6,7,8-tetrahydro-4H-chromen-4-one (89), and leptosphaerone (90) were isolated from the culture of Phoma sp. PF2, an endophyte of Artemisia princeps and all showed moderate inhibitory activities on nitric oxide levels in lipopolysaccharide-induced RAW264.7 macrophage cells [102].…”

Section: Anti-inflammatory Agents Produced By Endophyticmentioning

confidence: 99%

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Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Toghueo

2019

Nat. Prod. Bioprospect.

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Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

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Section: Anti-inflammatory Agents Produced By Endophyticmentioning

confidence: 99%

Section: Anti-inflammatory Agents Produced By Endophyticmentioning

confidence: 99%

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Toghueo

2019

Nat. Prod. Bioprospect.

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“…Endophytic fungus Asperigillus sp. CM9a recovered from the stems of C. mannii in China was found to produce cyclopentenedione, diketopiperazines, lactone, benzophenone, terpene, anthraquinone, diphenyl ethers, alkaloid, and isotryptoquivaline F, among which only isotrptoqivaline F had anti-TNF-α activity (Xue et al, 2014). However, the antimicrobial and cytotoxic potential of endophytic fungi residing in C. mannii has not been explored yet.…”

Section: Introductionmentioning

confidence: 99%

Screening and characterization of paclitaxel-producing fungus \(\textit{Talaromyces wortmannii}\) WQF18 isolated from \(\textit{Cephalotaxus mannii }\)Hook. f..

Tung

Anh

et al. 2023

AJB

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Cephalotaxus mannii Hook. f. is a rare evergreen conifer native listed in the International Union for Conservation of Nature (IUCN) Red List, which is utilized for leukemia treatment. Although endophytic fungi from C. mannii was reported before, their cytotoxic property has not been revealed yet. In the present study, a total of 7 endophytic fungi were isolated from C. mannii collected in Ha Giang province, Vietnam, among which the isolate WQF18 was active against 5 tested pathogens with inhibition zones ranging from 18.0 ± 0.7 to 25.0 ± 0.4 mm. In addition, only ethyl acetate extract of isolate WQF18 showed cytotoxicity on A549 and MCF7 cell lines with IC50 values of 69.6 ± 2.3 µg/mL and 78.6 ± 1.6 µg/mL, respectively. PCR-based molecular screening revealed that the positive hits for both 10-deacetylbaccatin III-10-O-acetyl transferase (dbat) and taxadiene synthase (ts) genes involved in paclitaxel biosynthesis were only observed in the WQF18 isolate. Based on morphological and molecular identification, the WQF18 isolate was identified as Talaromyces wortmannii WQF18. The presence of paclitaxel in T. wortmannii WQF18 was further confirmed by dbat sequence alignment, phenotypic, and HPLC-DAD analysis. To the best of our knowledge, this is the first report demonstrating the paclitaxel-producing capability of endophytic fungi from C. mannii. These findings provide a new platform for deciphering paclitaxel biosynthesis of endophytic fungi from non-Taxus plants and further paclitaxel production.

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