Isoxazoles

Reaction between isocyanides and nitrostyrenes in water: a novel and efficient synthesis of 5-(alkylamino)-4-aryl-3-isoxazolecarboxamides

“…Some isoxazoles are used as organic electrolytes in non-aqueous batteries, in photographic emulsions, and in fiber dyes. 2,3 Isoxazoles containing a 3-carboxamide or 5-amino substituent have been shown to possess antiepileptic, 4 anticonvulsant (e.g., D2624, Fig. 1), 5 antifungal, 6 and insecticidal 7 properties.…”

(E)-BenzaldehydeO-{[3-(pyridin-3-yl)isoxazol-5-yl]methyl}oxime

“…For organic synthesis of isoxazole systems, see: Giomi et al (2008); Chukanov & Reznikov (2011). For the biological activity of isoxazole systems, see: Meyers et al (2011); Basappa et al (2003); Lee et al (2009) ;Talley et al (2000); Farrerons et al (2003); Edgard et al (2004); For hydrogen-bond graph-set motifs, see: Etter (1990).…”

“…Many derivatives exhibit interesting applications in various fields such as agriculture, industry, and medicine. The wide spectrum of biological activities characteristic of these systems, comprises analgesic (Meyers et al, 2011), antifungal (Basappa et al, 2003), antiviral (Lee et al, 2009), anti-inflammatory (Talley et al, 2000), and antiobesity (Giomi et al, 2008) activities.…”

“…These compounds are used as intermediates in organic synthesis due to their easy transformation into important groups such as enamino ketones, enoximes, 1,3-dicarbonyl compounds, γ-amino alcohols, and β-hydroxy nitriles (Giomi et al, 2008;Chukanov & Reznikov, 2011).…”

Cerium(IV) ammonium nitrate for the tandem nitration and oxidative rearrangement of 2-acetyl-1-naphthol benzoylhydrazones into 1,2-diacylnaphthalenes; synthesis of benzo[f]phthalazines

“…31 Of the numerous articles on the synthesis, reactivity and bioactivity of isoxazoles and their arene-fused derivatives, the following have been gleaned to stress their significance. [34][35][36][37][38][39][40] It is of particular note that the ring is commonly built-up, either intra-or intermolecularly, through the engagement of an oxime entity, donating to the ring N-O bond. CAN-mediated transformation of acetone and acetophenone into nitrile oxides, followed by 1,3-dipolar cycloaddition with alkenes and alkynes, is a useful one-pot synthesis of 3-acetyl-and 3-benzoylisoxazole derivatives.…”