Ispaghula Husk-Based Extended Release Tablets of Diclofenac Sodium: Formulation, Evaluation and &lt;i&gt;In vitro&lt;/i&gt; Release Studies

Raja, D; Poornima, D. V.; Bhaskar, K.; Muniyandy, Saravanan

doi:10.4314/tjpr.v13i2.6

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…The diffractogram of Psy shows a broad diffused and widely scattered peak at 22°, indicating semi-crystalline nature as observed for most of the polysaccharides. Raja et al 22 have also reported similar results for XRD of Ispaghula-based extended release tablets. Similarly, XRD analysis of tamarind seed polysaccharide powder also showed amorphous structure.…”

Section: Xrd Analysissupporting

confidence: 52%

Microwave-assisted synthesis of carboxymethyl psyllium and its development as semi-interpenetrating network with poly(acrylamide) for gastric delivery

Bajpai

Chand

Agrawal

2015

Journal of Bioactive and Compatible Polymers

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In this study, microwave-induced synthesis of carboxymethyl psyllium is reported. The carboxymethyl psyllium was characterized by Fourier transform infrared, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and proton nuclear magnetic resonance spectroscopic analysis. It also showed fair antibacterial activity against model bacteria Escherichia coli, thus confirming its bioactivity. Its semi-interpenetrating polymer network hydrogels with poly(acrylamide) were synthesized and investigated for their swelling behavior in simulating gastric fluid at 37°C. The swelling ratio strongly depended on the degree of cross-linking and ratio of psyllium to acrylamide in the feed mixture. The kinetic water uptake data were interpreted by various kinetic models, and the order of fitness for these models was as follows: Power model > First-order model ≈ Schott model.

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Section: Xrd Analysissupporting

confidence: 52%

Microwave-assisted synthesis of carboxymethyl psyllium and its development as semi-interpenetrating network with poly(acrylamide) for gastric delivery

Bajpai

Chand

Agrawal

2015

Journal of Bioactive and Compatible Polymers

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“…The formulated tablets were further evaluated for physicochemical parameters by Fourier transform infrared spectroscopy (FTIR), as well as differential scanning calorimetry (DSC) and x-ray diffraction (XRD). The study revealed that the tablets formulated with 1:0.25 and 1:0.5 drug: husk ratio failed to extend the drug release whereas tablets prepared with 1:0.75 and 1:1 ratio were successful in extending release up to 5 and 6 h, respectively 43 .…”

Section: Pharmaceutical Applicationsmentioning

confidence: 96%

Untitled

2015

IJPSR

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Polysaccharides obtained from gums and mucilages are extensively used natural materials for conventional and novel dosage forms. Many natural gums are studied for use in novel drug delivery systems out of which polysaccharides, resins and tannins are most extensively studied and used. Because of advances in drug delivery technology, natural polysaccharides are included in novel drug delivery to fulfil multitask functions and in some cases directly or indirectly control the extent or rate of drug release. Regular research is going on in the field of use of naturally occurring biocompatible polymeric material in designing of dosage forms for oral controlled release administration. The natural polysaccharides improve the national economy by providing inexpensive formulations to people, by using locally available materials. The present review covers almost all the areas of interest of some very important naturally based polysaccharides, natural gums and mucilages with their sources, chemical constituents, chemical structures, isolation, purification, standardization and characterization along with their uses in various pharmaceutical formulations.

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“…It has gained attention in pharmaceutical drug delivery system for development of hydrophilic matrix and encapsulating microparticulate due to its swelling and gelling mass properties. 12 An attempt has been made to crosslink the husk with various synthetic polymers. Singh B. et al 13 modified husk with methacrylamide via 60 Co gamma radiation crosslinked polymerization for formulation of sustained release rifampicin hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium

Ale,

Nainwal,

Butola

et al. 2023

Ind. J. Pharm. Edu. Res.

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Introduction: Diclofenac Sodium (DS), a Non-Steroidal Anti-Inflammatory Drug (NSAID) is widely used in inflammation and pain management. However, the drug has a short half-life of 1.2-2 hr therefore, frequent administration of DS is required. In this research paper Inter-Penetrating Network (IPN) microspheres of Diclofenac sodium were made using Isabgol husk mucilage and Polyvinyl Alcohol (PVA) to prolong the release of diclofenac sodium. Isabgol husk is widely explored as a natural, economical, biocompatible, and biodegradable polymer for the development of a modified-release drug delivery system. Materials and Methods: IPN microspheres were prepared using Isabgol husk mucilage and Polyvinyl alcohol by emulsion cross-linking method in the presence of DL glyceraldehyde as a cross-linker. Evaluation: Fourier Transform Infrared (FTIR) spectroscopy was performed to confirm the formation of an interpenetrating network. The chemical stability of the drug and its molecular dispersion in the IPN was validated by X-ray Diffraction (XRD) analysis. The prepared microspheres were evaluated for % yield, drug loading, entrapment efficiency, surface morphology, swelling index and in vitro drug release. Results: The percentage yield and drug entrapment efficiency of the formulations were found in between 66.33 to 95.345%, and 40.24 to 68.12% respectively. The SEM and light microscopy studies confirmed the formation of spherical IPN microspheres. The model kinetics of in vitro release data found Korsmeyer-Peppas as the best-fit model for drug release from IPN microspheres.

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Ispaghula Husk-Based Extended Release Tablets of Diclofenac Sodium: Formulation, Evaluation and <i>In vitro</i> Release Studies

Cited by 6 publications

References 14 publications

Microwave-assisted synthesis of carboxymethyl psyllium and its development as semi-interpenetrating network with poly(acrylamide) for gastric delivery

Microwave-assisted synthesis of carboxymethyl psyllium and its development as semi-interpenetrating network with poly(acrylamide) for gastric delivery

Untitled

Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium

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