It Is All about Pressure

Brusini, Paolo; Salvetat, Maria Letizia; Zeppieri, Marco

doi:10.3390/jcm11133640

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings in the study have shown that there was neuroprotection from cell death in rat and mouse models of glaucoma that were fed with oral supplements of pyruvate [ 130 ]. Other clinical trials used nicotinamide and pyruvate in a phase II clinical trial and yielded significant momentary improvement in visual function, supporting the findings in the former experimental research and indicating a role for these agents in neuroprotection for individuals with glaucoma; this emphasizes the necessity for lasting studies to establish the longitudinal therapeutic effects of these nutrients [ 226 ], even if glaucoma has traditionally been exclusively all about pressure [ 227 ].…”

Section: Resultsmentioning

confidence: 63%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

Self Cite

View full text Add to dashboard Cite

Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

show abstract

Section: Resultsmentioning

confidence: 63%