It’s All in the Genes: How Genotype Can Impact Upon Response to Contaminant Exposure and the Implications for Biomonitoring in Aquatic Systems

Chung, Pann Pann; Hyne, Ross V.; Ballard, J. William O.

doi:10.5772/30911

Environmental Contamination 2012

DOI: 10.5772/30911

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It’s All in the Genes: How Genotype Can Impact Upon Response to Contaminant Exposure and the Implications for Biomonitoring in Aquatic Systems

Pann Pann Chung¹,

Ross V. Hyne²,

J. William O. Ballard³

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2015

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References 77 publications

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Leydig cell number and sperm production decrease induced by chronic ametryn exposure: a negative impact on animal reproductive health

Dantas

Cancian

Neodini

et al. 2015

Environ Sci Pollut Res

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Ametryn is an herbicide used to control broadleaf and grass weeds and its acute and chronic toxicity is expected to be low. Since toxicological data on ametryn is scarce, the aim of this study was to evaluate rat reproductive toxicity. Thirty-six adult male Wistar rats (90 days) were divided into three groups: Co (control) and T1 and T2 exposed to 15 and 30 mg/kg/day of ametryn, respectively, for 56 days. Testicular analysis demonstrated that ametryn decreased sperm number per testis, daily sperm production, and Leydig cell number in both treated groups, although little perceptible morphological change has been observed in seminiferous tubule structure. Lipid peroxidation was higher in group T2, catalase activity decreased in T1 group, superoxide dismutase activity diminished, and a smaller number of sulphydryl groups of total proteins were verified in both exposed groups, suggesting oxidative stress. These results showed negative ametryn influence on the testes and can compromise animal reproductive performance and survival.

show abstract

Leydig cell number and sperm production decrease induced by chronic ametryn exposure: a negative impact on animal reproductive health

Dantas

Cancian

Neodini

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

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It’s All in the Genes: How Genotype Can Impact Upon Response to Contaminant Exposure and the Implications for Biomonitoring in Aquatic Systems

Cited by 1 publication

References 77 publications

Leydig cell number and sperm production decrease induced by chronic ametryn exposure: a negative impact on animal reproductive health

Leydig cell number and sperm production decrease induced by chronic ametryn exposure: a negative impact on animal reproductive health

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