Itch characteristics in atopic dermatitis: results of a web-based questionnaire

Dawn, Aerlyn G.; Papoiu, Alexandru D.P.; Chan, Yiong Huak; Rapp, Stéphen R.; Rassette, N.; Yosipovitch, Gil

doi:10.1111/j.1365-2133.2008.08941.x

Cited by 159 publications

(132 citation statements)

References 6 publications

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“…Dies wird jedoch oft nicht der Dynamik, den tageszeitlichen Schwankungen und der Schwere des Symptoms sowie der psychosozialen Belastung gerecht. In den letzten Jahren wurden Fragebögen zur Erfassung und Dokumentation von Pruritus bei bestimmten Erkrankungen entwickelt und eingesetzt [6,8,9,27,30,31,32]. In deutscher Sprache steht seit 1997/2001 der Eppendorfer Juckreizfragebogen zur Verfügung [6,8].…”

Section: Hintergrund Und Erste Ergebnisseunclassified

Entwicklung eines deutschsprachigen Fragebogens zur Erfassung von chronischem Pruritus (AGP-Fragebogen)

et al. 2011

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Chronic pruritus may manifest itself clinically in terms of different duration, intensity and quality. There is no questionnaire assessing these parameters systematically. The study presents a pruritus questionnaire for the German speaking region (AGP-Questionnaire) developed by 4 experts in the field. It comprises questions on course, intensity and quality of pruritus, general health status, sociodemographic data, quality of life (QoL) and pruritus cognition. Standardised questionnaires such as the SF-12 Health Survey (recall period 4 weeks), the Hospital Anxiety and Depression Scale (HADS) and the Dermatology Life Quality Index (DLQI) were also used to assess the instrument's convergent validity. Feedback of the participants was obtained by a one-page evaluation sheet. 100 patients suffering from chronic pruritus of the university hospitals of Giessen, Heidelberg, Munich and Muenster participated in the study. This questionnaire is useful in providing a comprehensive and structured approach to assessing individual patients' chronic pruritus. The validity and sensitivity of this new pruritus questionnaire will require examination in further studies.

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Section: Hintergrund Und Erste Ergebnisseunclassified

Entwicklung eines deutschsprachigen Fragebogens zur Erfassung von chronischem Pruritus (AGP-Fragebogen)

et al. 2011

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“…This hedonic experience is associated with activation of the reward system including the midbrain, striatum, anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) (Papoiu et al, 2013;Mochizuki et al, 2014). Studies using questionnaires have demonstrated that chronic itch patients rate scratching as pleasurable and that correlated well with their itch intensity (Dawn et al, 2009;O'Neil et al, 2011). It was also reported that in chronic itch patients, despite being initially somewhat pleasurable, scratching could lead to a counterproductive effect: an increase in the intensity of itch, which contrasts with the effect of scratching in healthy volunteers (Ishiuji et al, 2008).…”

Section: Introductionmentioning

confidence: 96%

Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch Patients

Mochizuki

Papoiu

Nattkemper

et al. 2015

Journal of Investigative Dermatology

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Scratching evokes a rewarding and pleasurable sensation, particularly in chronic itch patients. To date, no study has investigated the cerebral activity during scratching in chronic itch patients and whether it differs from that in healthy subjects. Using arterial spin labeling functional magnetic resonance imaging, we analyzed and compared the cerebral mechanism of self-scratching and its correlation with pleasurability in 10 patients with chronic itch and in 10 healthy controls. Cowhage was applied to the right forearm to induce itch. Scratching significantly attenuated the itch sensation (P<0.001) and evoked an associated pleasurability. Scratching-induced pleasurability significantly activated the reward system in the chronic itch and healthy groups, confirming that this reward system has a crucial role in scratching-induced pleasurability. A higher activity during scratching in chronic itch patients, versus healthy controls, was noted in brain regions related to motor control and motivation to act, including the supplementary motor area, premotor cortex, primary motor cortex, and midcingulate cortex, as well as the caudate nucleus involved in the reward system. This overactivity may be associated with the addictive scratching and/or neural hypersensitization.

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“…Heat may play a harmful role in some AD patients by provoking perspiration, which is one of the most commonly reported aggravants in children with AD [139][140][141][142][143]. Perspiration may have an irritant effect on the skin mediated by the acidic pH of sweat, possibly promoting Th-2 inflammation [88], increased cutaneous blood flow due to vasodilation in hot environments [142], and possibly a neuroanatomic mechanism mediated by C nerve fibers [144].…”

Section: Climatementioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Itch characteristics in atopic dermatitis: results of a web-based questionnaire

Cited by 159 publications

References 6 publications

Entwicklung eines deutschsprachigen Fragebogens zur Erfassung von chronischem Pruritus (AGP-Fragebogen)

Entwicklung eines deutschsprachigen Fragebogens zur Erfassung von chronischem Pruritus (AGP-Fragebogen)

Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch Patients

Environmental risk factors and their role in the management of atopic dermatitis

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