Itch Characteristics in Five Dermatoses: Non-atopic Eczema, Atopic Dermatitis, Urticaria, Psoriasis and Scabies

Brenaut, E.; Garlantézec, Ronan; Talour, Karen; Miséry, Laurent

doi:10.2340/00015555-1599

Cited by 52 publications

(68 citation statements)

References 7 publications

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“…Although AP is very well known in PV, few publications have reported it during the course of essential thrombocythaemia (ET) or myelofibrosis (MF), and data about its prevalence and characteristics in these pathologies remain lacking . We conducted a prospective study using a questionnaire that was adapted from a previous form on 70 patients with MPN (43 PV, 15 ET, 12 MF; all patients were positive for Janus kinase V617F mutation) who reported AP at onset or later during the course of MPN . Clinical data for the patients and details of the methods are provided in Appendix S1 and Table S1 (see Supporting Information).…”

Section: Clinical Characteristics Of Aquagenic Pruritus (Ap) In Each supporting

confidence: 84%

Clinical characteristics of aquagenic pruritus in patients with myeloproliferative neoplasms

et al. 2016

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Section: Clinical Characteristics Of Aquagenic Pruritus (Ap) In Each supporting

confidence: 84%

Clinical characteristics of aquagenic pruritus in patients with myeloproliferative neoplasms

et al. 2016

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“…10,41 Notably, the pathoetiology of these conditions have also been tightly associated with TRPA1. 14,42,52 In lieu of the significant differences in pain processing, pain sensitivity and TRP-expression between different tissues and anatomical locations 13,27,35,36 , the CA pain model probably needs to be re-implemented in various tissues if to, for instance, mimic mucosal inflammation and pain associated with e.g., throat soreness.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…Five ramp stimuli from 0-110 g at a rate of 5g/1 sec with the default stimulus probe were conducted at different locations within the application area. The subjects were instructed to continuously rate the perceived pain on the coVAS ranging from "No pain" (0) to "worst imaginable pain" (10). The arithmetic mean of the VAS scores yielded three MPTs (fixed to VAS = 0.5, 1 and 2) and an area-under-the-curve (AUC).…”

Section: Mechanical Sensitivitymentioning

confidence: 99%

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Andersen

Gazerani

Arendt-Nielsen

2016

The Journal of Pain

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Drugs interacting with transient receptor potential channels are of great therapeutic potential. In the present study we established cutaneous pain and hyperalgesia using the TRPA1 agonist CA. Subsequently, we showed that the frequently used topical counterirritant and TRPM8 agonist, L-menthol, decreased evoked pain, hyperalgesia, and inflammation, indicating direct and indirect antinociceptive mechanisms.

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“…[121314] Although the intensity of itching in different phenotypes of GVHD is different, no comparison has been performed so far. Based on our results, we found that the intensity of itching was much stronger in patients with AD-like GVHD than that in patients with LP-like GVHD.…”

Section: Discussionmentioning

confidence: 99%

Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease

Chen

et al. 2017

Chinese Medical Journal

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Background:Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation. Skin barrier disruption could induce thymic stromal lymphopoietin (TSLP) expression, and the expression of TSLP was increased in lesions of atopic dermatitis (AD)-like GVHD and lichen planus (LP)-like GVHD. This study attempted to investigate the skin barrier function of AD-like GVHD and LP-like GVHD and possible mechanisms.Methods:Eighteen AD-like GVHD patients, 12 LP-like GVHD patients, and 14 healthy volunteers were enrolled in this study. Skin biopsy was done in five AD-like GVHD patients, eight LP-like GVHD patients, and eight healthy volunteers. The intensity of pruritus was assessed by visual analog scale itch score and detailed pruritus score. Transepidermal water loss (TEWL) was measured using Tewameter® TM 300. Immunohistochemistry was used to observe the expression of loricrin, involucrin, LL37, and human β-defensins 2 (hBD2) in skin lesions. Western blot analysis was used for analyzing the protein levels of loricrin and involucrin in skin lesions. Real-time polymerase chain reaction was performed to assess the mRNA levels of LL37 and hBD2 in skin lesions.Results:Pruritus score was higher in patients with AD-like GVHD (11.33 ± 5.35) than that of patients with LP-like GVHD (2.58 ± 3.09, P < 0.001). Compared with healthy controls (HCs, 4.52 ± 1.24 g·m−2·h−1), TEWL was increased in AD-like GVHD (26.72 ± 9.02 g·m−2·h−1, P < 0.001) and LP-like GVHD patients (18.78 ± 4.57 g·m−2·h−1, P < 0.001), and expressions of loricrin and involucrin were also increased in skin lesions of AD-like GVHD and LP-like GVHD patients (all P < 0.05). LL37 mRNA expression was decreased in lesions of AD-like GVHD and LP-like GVHD patients (P = 0.005 and P = 0.008, vs. HCs, respectively). hBD2 mRNA expression was increased in skin lesions of AD-like GVHD and LP-like GVHD patients (P = 0.002 and P < 0.001, vs. HCs, respectively).Conclusions:Skin barrier dysfunction is present in AD-like GVHD and LP-like GVHD. The immunoreactions, but not the congenital defect, are considered to be the primary cause of skin barrier impairment in AD-like GVHD and LP-like GVHD.

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Itch Characteristics in Five Dermatoses: Non-atopic Eczema, Atopic Dermatitis, Urticaria, Psoriasis and Scabies

Cited by 52 publications

References 7 publications

Clinical characteristics of aquagenic pruritus in patients with myeloproliferative neoplasms

Clinical characteristics of aquagenic pruritus in patients with myeloproliferative neoplasms

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease

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