Itchy channels and where to find them

Gamper, Nikita

doi:10.1113/jp274199

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Pruritus1

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2018

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Cited by 1 publication

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“…Ablation of TRPA1 blocks itch in a dry skin mouse model of chronic itch. Mice lacking TRPA1 exhibit no scratch following subcutaneous injections of chloroquine and BAM8–22, but do scratch in response to α-methyl-5HT [ 17 , 32 ]. Voltage-gated sodium channel (NaV) 1.7 has also been found to mediate itch.…”

Section: Pruritusmentioning

confidence: 99%

Antipruritic Effects of Botulinum Neurotoxins

Gazerani

2018

Toxins

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This review explores current evidence to demonstrate that botulinum neurotoxins (BoNTs) exert antipruritic effects. Both experimental and clinical conditions in which botulinum neurotoxins have been applied for pruritus relief will be presented and significant findings will be highlighted. Potential mechanisms underlying antipruritic effects will also be discussed and ongoing challenges and unmet needs will be addressed.

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Section: Pruritusmentioning

confidence: 99%

Antipruritic Effects of Botulinum Neurotoxins

Gazerani

2018

Toxins

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show abstract

Itchy channels and where to find them

Cited by 1 publication

References 17 publications

Antipruritic Effects of Botulinum Neurotoxins

Antipruritic Effects of Botulinum Neurotoxins

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