ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis

Chen, Geng; Xiong, Lv; Wang, Yumeng; He, Libo; Huang, Rong; Liao, Lanjie; Zhang, Zhu; Wang, Yaping

doi:10.3390/ijms19103175

Cited by 15 publications

(7 citation statements)

References 49 publications

(51 reference statements)

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“…Virus entry into animal cells, the first step to launch a disease, is initiated by attachment to receptors and followed by penetration through (non-enveloped viruses) or fusion with (enveloped viruses) cellular membranes [14]. Pioneering studies have suggested that tight crosstalk between viral structure proteins (e.g., VP5, VP7, VP35) and host machinery (e.g., endosome, microtubules, dynamin, receptors, HSPs) are involved in the viral entry of GCRV infection [15][16][17][18][19][20][21]. However, our understanding of the temperature-dependent GCRV pathogenesis is still in its infancy.…”

Section: Introductionmentioning

confidence: 99%

An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry

Hou

Liu

et al. 2023

PLoS Pathog

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Viral seasonality in the aquaculture industry is an important scientific issue for decades. While the molecular mechanisms underpinning the temperature-dependent pathogenesis of aquatic viral diseases remain largely unknown. Here we report that temperature-dependent activation of IL6-STAT3 signaling was exploited by grass carp reovirus (GCRV) to promote viral entry via increasing the expression of heat shock protein 90 (HSP90). Deploying GCRV infection as a model system, we discovered that GCRV induces the IL6-STAT3-HSP90 signaling activation to achieve temperature-dependent viral entry. Further biochemical and microscopic analyses revealed that the major capsid protein VP7 of GCRV interacted with HSP90 and relevant membrane-associated proteins to boost viral entry. Accordingly, exogenous expression of either IL6, HSP90, or VP7 in cells increased GCRV entry in a dose-dependent manner. Interestingly, other viruses (e.g., koi herpesvirus, Rhabdovirus carpio, Chinese giant salamander iridovirus) infecting ectothermic vertebrates have evolved a similar mechanism to promote their infection. This work delineates a molecular mechanism by which an aquatic viral pathogen exploits the host temperature-related immune response to promote its entry and replication, instructing us on new ways to develop targeted preventives and therapeutics for aquaculture viral diseases.

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Section: Introductionmentioning

confidence: 99%

An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry

Hou

Liu

et al. 2023

PLoS Pathog

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“…[82][83][84] Other challenges may include ancestral whole-genome duplication and mosaicism. [85][86][87][88][89][90][91] Mosaicism occurs when CRISPR/Cas nucleases retain activity after the first event of embryo cleavage, resulting in varying combinations of mutations among cell lineages. 92 All teleosts went through three rounds of genome duplication throughout vertebrate evolution.…”

Section: Clustered Regularly Interspaced Palindromic Repeats/cas9mentioning

confidence: 99%

Optimising commercial traits through gene editing in aquaculture: Strategies for accelerating genetic improvement

Moran,

Jones,

Jensen

et al. 2023

Reviews in Aquaculture

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Aquaculture is one of the fastest‐growing food production sectors. As the global human population continues to increase and further pressure is added to the prospects of achieving global food security, aquaculture is expected to play an integral role in meeting future nutrition demands. With advances in genetic technologies over recent years, much progress has been made within the realm of selective breeding. Despite success, selective breeding programs have limitations to the rate of genetic gain they can achieve. The incorporation of targeted genetic technologies, such as gene editing, into research related to selective breeding programs will help identify specific genes related to commercially desirable traits, as well as expedite genetic improvement. This review summarises research encompassing the most commonly targeted traits using gene editing within aquaculture, namely reproduction and development, pigmentation, growth and disease resistance. In addition, this review illustrates how the incorporation of gene editing can expedite genetic improvement through the rapid fixation of desirable alleles, as well as suggests strategies to accelerate genetic improvement for aquaculture production.

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“…Fish infected with GCRV produce a symptom reaction 4 days after infection. After 5-7 days, the fish show obvious hemorrhagic symptoms, and the fish population enters the peak of mortality [102]. Because of its high risk, wide prevalence, and long onset season, this virus has been the focus of research on fish viruses, but there is not yet an effective treatment [103].…”

Section: Medicinal Plants Against Gcrvmentioning

confidence: 99%

Review of Medicinal Plants and Active Pharmaceutical Ingredients against Aquatic Pathogenic Viruses

Liao

Huang

Han

et al. 2022

Viruses

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Aquaculture offers a promising source of economic and healthy protein for human consumption, which can improve wellbeing. Viral diseases are the most serious type of diseases affecting aquatic animals and a major obstacle to the development of the aquaculture industry. In the background of antibiotic-free farming, the development and application of antibiotic alternatives has become one of the most important issues in aquaculture. In recent years, many medicinal plants and their active pharmaceutical ingredients have been found to be effective in the treatment and prevention of viral diseases in aquatic animals. Compared with chemical drugs and antibiotics, medicinal plants have fewer side-effects, produce little drug resistance, and exhibit low toxicity to the water environment. Most medicinal plants can effectively improve the growth performance of aquatic animals; thus, they are becoming increasingly valued and widely used in aquaculture. The present review summarizes the promising antiviral activities of medicinal plants and their active pharmaceutical ingredients against aquatic viruses. Furthermore, it also explains their possible mechanisms of action and possible implications in the prevention or treatment of viral diseases in aquaculture. This article could lay the foundation for the future development of harmless drugs for the prevention and control of viral disease outbreaks in aquaculture.

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ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis

Cited by 15 publications

References 49 publications

An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry

An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry

Optimising commercial traits through gene editing in aquaculture: Strategies for accelerating genetic improvement

Review of Medicinal Plants and Active Pharmaceutical Ingredients against Aquatic Pathogenic Viruses

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