ITGB2 (CD18) mRNA Expression in Hirschsprung-Associated Enterocolitis (HAEC)

Mariana, Nita; Islam, Andi Asadul; Massi, Maurizio; Warsinggih,; Hatta, Mochammad; Patellongi, Ilhamjaya

doi:10.5958/0976-5506.2019.02029.1

Cited by 2 publications

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“…As a result of abnormal intestinal motility that allows bacterial stasis and microflora dis-equilibrium, coupled with an innate immune response and several other mechanisms from the level of gene expression to the biochemical imbalance of the digestive tract, will cause intestinal barrier complex disorders that will appear as histopathological changes in bowel wall structure. 4,5,[7][8][9][10][11] Other theories that have been proven are the retention of mucin in the colonic mucosa, as well as the shift from acidity of the mucin to neutral. 12 It was proposed that HAEC patients will sustain significant changes in theirbowel tissue characterized by mucin retention and dilatation of crypts which becomes the basis of HAEC histopathological classification.…”

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confidence: 99%

“…It was suggested that HAEC scores with cut-off 4 would increase sensitivity and specificity to detect HAEC episodes. 6,15 Although several indicators have been investigated, [8][9][10] only the HAEC score is the easiest and most applicable in daily use for enterocolitis in HRSC. The absence of gold standard diagnostic tool for HAEC causes many delays in diagnosis that are parallel with the over and under treatment of this condition.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological changes and Hirschsprung’s associated enterocolitis (HAEC) scores

et al. 2020

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Histopathological changes that are usually permanent in the bowel of Hirschsprung's disease (HRSC) in children make susceptibility to the incidence of enterocolitis even after definitive therapy. The pathophysiology of HRSC is characterized by specific signs, and symptoms. Scoring system has been applied in diagnosis of Hirschsprung's associated enterocolitis (HAEC) due to its simplest and easiest. However, after a decade it has been several evaluated to obtain optimal benefits in the clinical setting. The aim of this study was to investigate the relationship between histopathological grade of enterocolitis and HAEC scores. Children with HRSC who underwent leveling colostomy or pull-through were sampled from the ganglionic segment. Those with a histopathological description of HAEC were included in the study. HAEC scores were evaluated retrospectively through medical records and interviews. Data were analyzed using the Spearman's Rank test. Twenty eight samples were involved in this study. The population was dominated by male (82.1%) and almost half the population (42.9%) were infants. The distribution of the histopathological grade was fairly even, except for grade V where it was only 7.2% of the total sample. Grade I & III samples were 21.4%, while grade II & IV were 25%, respectively. A significant relationship between histopathological grade and HAEC score was obtained (r = 0.927; p<0.0001). In conclusion, there is a relationship between the histopathological grade of enterocolitis and HAEC scores.

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confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histopathological changes and Hirschsprung’s associated enterocolitis (HAEC) scores

et al. 2020

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Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis

Zhang

et al. 2023

IJMS

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Despite the significant progress that has been made in terms of understanding the pathophysiology and risk factors of Hirschsprung-associated enterocolitis (HAEC), the morbidity rate has remained unsatisfactorily stable, and clinical management of the condition continues to be challenging. Therefore, in the present literature review, we summarized the up-to-date advances that have been made regarding basic research on the pathogenesis of HAEC. Original articles published between August 2013 and October 2022 were searched in a number of databases, including PubMed, Web of Science, and Scopus. The keywords “Hirschsprung enterocolitis”, “Hirschsprung’s enterocolitis”, “Hirschsprung’s-associated enterocolitis”, and “Hirschsprung-associated enterocolitis” were selected and reviewed. A total of 50 eligible articles were obtained. The latest findings of these research articles were grouped into gene, microbiome, barrier function, enteric nervous system, and immune state categories. The present review concludes that HAEC is shown to be a multifactorial clinical syndrome. Only deep insights into this syndrome, with an accrual of knowledge in terms of understanding its pathogenesis, will elicit the necessary changes that are required for managing this disease.

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ITGB2 (CD18) mRNA Expression in Hirschsprung-Associated Enterocolitis (HAEC)

Cited by 2 publications

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Histopathological changes and Hirschsprung’s associated enterocolitis (HAEC) scores

Histopathological changes and Hirschsprung’s associated enterocolitis (HAEC) scores

Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis

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