ITP of lanthanides in microfluidic PMMA chip

Cong, Yongzheng; Bottenus, Danny; Liu, Bingwen; Clark, Sue B.; Ivory, Cornelius F.

doi:10.1002/elps.201300382

Cited by 14 publications

(18 citation statements)

References 48 publications

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“…The ITP separation of eight lanthanides on a serpentine poly(methyl methacrylate) microchip with a tee junction, a serpentine channel, and contactless conductivity detection was developed by Cong et al. . Acetate and α‐hydroxyisobutyric acid were used as complexing agents to increase the electrophoretic mobility difference between the lanthanides (LE: 10 mM NH 4 Ac, 7 mM α‐hydroxyisobutyric acid, 1% PVP, pH 4.5; TE: 10 mM HAc, 7 mM α‐hydroxyisobutyric acid, 1% PVP, pH 3.0).…”

Section: Applicationsmentioning

confidence: 99%

Recent progress in analytical capillary isotachophoresis

2014

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This paper brings a survey of papers on analytical capillary ITP published since 2012 until the first quarter of 2014. These papers are ranged according to their nature, the techniques used, and the instrumentation employed. The sequence of the related chapter titles is as follows: Theory and simulations, techniques and instrumentation, single-column and column-switching applications of ITP, ITP in microfluidic systems, on-line ITP-CZE and transient ITP (tITP) techniques and applications. The review shows the position of analytical capillary ITP among contemporary separation techniques and implies the potential future trends.

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Section: Applicationsmentioning

confidence: 99%

Recent progress in analytical capillary isotachophoresis

2014

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“…[44][45][46] The analyte of interest is focused at the interface of two distinct electrolyte solutions resulting in a fi nite zone of highly concentrated analyte. Typically, ITP is performed on nonconductive planar substrates (e.g., glass and plastics), [ 44,[47][48][49] while recently successful ITP focusing was also demonstrated in porous media such as paper. [ 50,51 ] In this work, we design a novel proof-of-concept assay that interfaces PSi Fabry-Pérot interferometry with ITP and demonstrates its applicability for highly sensitive optical detection of DNA oligonucleotides.…”

Section: Introductionmentioning

confidence: 99%

Oxidized Porous Silicon Nanostructures Enabling Electrokinetic Transport for Enhanced DNA Detection

Vilensky

Bercovici

Segal

2015

Adv Funct Materials

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Nanostructured porous silicon (PSi) is a promising material for the label-free detection of biomolecules, but it currently suffers from limited applicability due to poor sensitivity, typically in micromolar range. This work presents the design, operation concept, and characterization of a novel microfl uidic device and assay that integrates an oxidized PSi optical biosensor with electrokinetic focusing for a highly sensitive label-free detection of nucleic acids. Under proper oxidation conditions, the delicate nanostructure of PSi can be preserved, while providing suffi cient dielectric insulation for application of high voltages. This enables the use of signal enhancement techniques, which are based on electric fi elds. Here, the DNA target molecules are focused using an electric fi eld within a fi nite and confi ned zone, and this highly concentrated analyte is delivered to an on-chip PSi Fabry-Pérot optical transducer, prefunctionalized with capture probes. Using refl ective interferometric Fourier transform spectroscopy real-time monitoring, a 1000-fold improvement in limit of detection is demonstrated compared to a standard assay, using the same biosensor. Thus, a measured limit of detection of 1 × 10 −9 M is achieved without compromising specifi city. The concepts presented herein can be readily applied to other ionic targets, paving way for the development of other highly sensitive chemical and biochemical assays.

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“…Despite these benefits, the only demonstration of lanthanides separation conducted completely on a MFD utilizing ITP is performed in a serpentine PMMA microchannel by Cong et al. using eight different lanthanides .…”

Section: Introductionmentioning

confidence: 99%

Design and optimization of a fused‐silica microfluidic device for separation of trivalent lanthanides by isotachophoresis

et al. 2019

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DOI: https://doi.org/10.1002/elps.201900027 This cover picture shows the elemental separation of critical materials (rare earths) within a microfluidic channel using embedded electrodes. The embedded electrodes allow for fast manipulation of voltages in microfluidic channel. Electrophoresis is a powerful and green route to separating these chemically similar species and enabling fast, accurate analysis of the chemical species to further sourcing and processing options for these economically essential elements.

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ITP of lanthanides in microfluidic PMMA chip

Cited by 14 publications

References 48 publications

Recent progress in analytical capillary isotachophoresis

Recent progress in analytical capillary isotachophoresis

Oxidized Porous Silicon Nanostructures Enabling Electrokinetic Transport for Enhanced DNA Detection

Design and optimization of a fused‐silica microfluidic device for separation of trivalent lanthanides by isotachophoresis

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