2015
DOI: 10.1016/j.neuroscience.2015.04.006
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iTRAQ-based quantitative analysis of hippocampal postsynaptic density-associated proteins in a rat chronic mild stress model of depression

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Cited by 67 publications
(48 citation statements)
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“…6b,c). This observation held true when the vPSD was obtained by comparing zebrafish PSD proteins with human53233, mouse383940 and rat34353637 PSD proteomes (median vPSD protein identity 66% and median mammalian-specific PSD protein identity 61.5%; significantly different, Mann–Whitney U -test, P <0.0001). Fifth, we asked whether the species-specific PSD (Zf-sPSD and Mm-sPSD) proteins also showed this high conservation, and found that they were significantly lower, even when compared with whole-brain proteomes (Fig.…”
Section: Resultsmentioning
confidence: 85%
“…6b,c). This observation held true when the vPSD was obtained by comparing zebrafish PSD proteins with human53233, mouse383940 and rat34353637 PSD proteomes (median vPSD protein identity 66% and median mammalian-specific PSD protein identity 61.5%; significantly different, Mann–Whitney U -test, P <0.0001). Fifth, we asked whether the species-specific PSD (Zf-sPSD and Mm-sPSD) proteins also showed this high conservation, and found that they were significantly lower, even when compared with whole-brain proteomes (Fig.…”
Section: Resultsmentioning
confidence: 85%
“…Modifications of the GluN2A-containing NMDARs have been implicated in several pathological conditions including among others cerebral ischemia [148], depression [149][150][151][152][153][154][155][156], anxiety [149,157], schizophrenia [158][159][160][161], and Huntington's disease [162][163][164]. In this review we decided to focus our attention on selected brain disorders in which GluN2A disfunctions is strictly correlated to altered synaptic plasticity, such as epilepsy, Alzheimer's disease, Parkinson's disease, Fragile-X Syndrome, and autism.…”
Section: Role Of Glun2a In Pathological Plasticitymentioning
confidence: 99%
“…After 2 h of incubation at room temperature, labeled samples were mixed at equal ratios. Subsequently, labeled peptides were combined and fractionated by strong cation exchange (SCX) chromatography (Han et al, 2015) and desalted on C18 Cartridges (66872-U; Sigma, St. Louis, MO, USA). The dried peptide mixture was reconstituted and acidified with 2 mL buffer A (10 mM KH 2 PO 4 in 25% of ACN, pH 3.0) and loaded onto a column (4.6 × 250 mm).…”
Section: Protein Extraction and Quantification Itraq Labeling And Smentioning
confidence: 99%