2024
DOI: 10.21203/rs.3.rs-4646012/v1
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iTRAQ proteomic analysis of exosomes derived from synovial fluid reveals disease patterns and potential biomarkers of Osteoarthritis

Xiaomin Wu,
Huaiming Li,
Huichun Zou
et al.

Abstract: The exosomes derived from synovial fluid (SF-exo) are indicative of the condition of the originating cell. The proteomics profiles of SF-exo are of great interest for the diagnosis of Osteoarthritis (OA). To delineate the proteomic differences between SF-exo from OA patients and those from healthy individuals, an iTRAQ quantitative proteomics was performed. A total of 439 proteins were identified, with 20 proteins exhibiting increased expression and 5 showing decreased expression in OA group. Bioinformatic ana… Show more

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