J Wave Is Better Left Alone?

Nakao, Yoko M.; Miyamoto, Yoshihiro

doi:10.1253/circj.cj-15-0920

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Recent studies have shown that the prevalence of J-waves in a general population ranges from 0.9% to 24.8%, 27,28) and that male gender is a factor associated with J-waves partly through the effect of testosterone. 18,[29][30][31] Consistent with these findings, the present study results revealed that J-waves were more frequent in male than female subjects.…”

Section: Characteristics Of the Study Population And J-wave Morphologymentioning

confidence: 99%

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan

et al. 2018

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We previously showed that J-waves were found more frequently in patients with low levels of serum eicosapentaenoic acid (EPA) in the acute phase of myocardial infarction, and were associated with the incidence of ischemia-related ventricular arrhythmias. However, the relationship between J-waves and serum EPA levels in a general population remains to be elucidated.The Iwaki Health Promotion Project is an ongoing community-based health promotion study in Iwaki, Hirosaki, which is in northern Japan. A total of 1,052 residents (mean age, 53.9 ± 15.4 years; 390 men) who participated in this project in 2014 were studied. A standard 12-lead electrocardiogram (ECG) was recorded and serum EPA levels were measured to evaluate the relationship between J-waves and serum EPA levels. J-waves were found in 52 (5%) subjects and were observed more frequently in male than female subjects (44 [11%] versus 8 [1%], P < 0.0001). More than half of the J-waves were the notched type (60%), and J-waves were detected most frequently in inferior leads on ECG (52%). The RR interval was longer and QTc duration shorter in subjects with J-waves than those without. No significant difference was found in serum EPA levels between subjects with and without J-waves (70 [49-116] versus 65 [41-106] μg/mL, P = 0.40). In multivariate analysis, male gender and RR interval were independent factors associated with the presence of J-waves.There was no significant relationship between J-waves and serum EPA levels in this general population in Japan. Various mechanisms for manifestation of the J-waves are suggested.

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Section: Characteristics Of the Study Population And J-wave Morphologymentioning

confidence: 99%

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan

et al. 2018

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“…ERS is characterized by J point elevation on surface ECGs, and the J wave is characterized by dynamic morphological changes that show a hump, notch, or slur at the end of the QRS complex on surface ECGs. Global prevalence of the J wave in the general population varies widely from 0.9% to 24.8% [23] , which depends on the ethnicity, age, gender, and the diagnostic criteria of the J wave itself. ERS was formerly considered a normal benign repolarization variant, but the cumulative evidence, since 2008, indicates that ERS contains a possible risk of lethal VT/VF and sudden cardiac death (SCD) [24] .…”

Section: Discussionmentioning

confidence: 99%

Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome

Maruyama

Fujita

Irie

et al. 2017

Journal of Arrhythmia

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Acetylcholine is widely used for a diagnostic provocation test of coronary spasm in patients with vasospastic angina. Acetylcholine usually induces coronary vasodilatation mediated by muscarinic receptor activation, but sometimes it evokes vasoconstriction of coronary arteries where the endothelium is damaged. Early repolarization syndrome is characterized by a J wave observed at the end of the QRS complex in a surface electrocardiogram. The J wave is attributed to the transmural voltage gradient at the early repolarization phase across the ventricular wall, which stems mainly from prominent transient outward current in the epicardium, but not in the endocardium. Transient high-dose application of acetylcholine into the epicardial coronary arteries provides a unique opportunity to augment net outward current, selectively, in the ventricular epicardium and unmask the J wave, irrespective of the cardiac ischemia based on coronary spasm. Acetylcholine augments cardiac membrane potassium conductance by enhancing acetylcholine-activated potassium current directly and by activating adenosine triphosphate-sensitive potassium current, in addition to the reduced sodium and calcium currents in the setting of severe ischemia due to vasospasm. However, the role of acetylcholine as an arrhythmogenic probe of the J wave induction in patients with suspected early repolarization syndrome warrants future prospective study.

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J Wave Is Better Left Alone?

Cited by 2 publications

References 17 publications

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan

Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome

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