Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo

Jacaric Acid is Rapidly Metabolized to Conjugated Linoleic Acid in Rats

“…In our previous studies, we have shown that the anti-tumor activity of CLnAs is stronger than that of CLAs and that JA has the strongest effect among CLnAs 11,15 . These results suggest that JA may be a useful physiologically active substance that may have important applications in humans.…”

“…Key words: conjugated fatty acid, conjugated linolenic acid, conjugated linoleic acid, jacaric acid, lymph had the strongest effect among CLnAs 15 . JA is a natural product that is present in jacaranda seed 10 and may have applications in humans as a useful physiologically active fatty acid.…”

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

“…It is the sole source of natural c8, t10, c12 octadecatrienoic acid, called jacaric acid JA , which is a type of CLN. A recent study revealed that JA has the most potent cytotoxic effects on human colon cancer cells 9 . On the other hand, other fatty acids such as linoleic acid LA , oleic acid, and palmitoleic acid, interfere with the cytotoxic effects of CLA on cancer cells 10,11 .…”

Research on food and nutrition characteristics of conjugated fatty acids

“…16) Moreover, conjugated EPA and conjugated DHA have also been shown to have strong antitumor effects. [17][18][19] The aforementioned experiments showed that the cancer suppression effect of ESA was stronger than that of CLA. In addition, it was found that the cancer tissue collected from the ESA-administered mice showed internal discoloration and necrosis, indicating that nutrition did not reach the tissue interior because vessels that would have transported nutrients were never formed.…”