2014
DOI: 10.3892/ol.2014.2168
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JAK2 V617F detected in two B-cell chronic lymphocytic leukemia patients without coexisting Philadelphia chromosome-negative myeloproliferative neoplasms: A report of two cases

Abstract: The JAK2 V617F mutation has been observed in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs), including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. This mutation has also been observed in a small number of other myeloid malignancies, such as acute myeloid leukemia, chronic myeloid leukemia and myelodysplastic syndrome. The JAK2 V617F allele has rarely been evaluated in lymphoproliferative disorders. In total, 28 JAK2 V617F-positive B-cell lym… Show more

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Cited by 5 publications
(4 citation statements)
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References 30 publications
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“…There are some cases of B-cell chronic lymphocytic leukaemia (B-CLL) with JAK2V617F mutation described: some of them presented first with MPN and afterwards progressed to CLL, others were diagnosed first with CLL and then with MPN. There were also two published cases of B-CLL with JAK2V617F mutation without any data of MPN [93]. Based on this, MPN and B-CLL may be originating from common progenitors.…”
Section: Thrombocytopenia Due To Etmentioning
confidence: 76%
“…There are some cases of B-cell chronic lymphocytic leukaemia (B-CLL) with JAK2V617F mutation described: some of them presented first with MPN and afterwards progressed to CLL, others were diagnosed first with CLL and then with MPN. There were also two published cases of B-CLL with JAK2V617F mutation without any data of MPN [93]. Based on this, MPN and B-CLL may be originating from common progenitors.…”
Section: Thrombocytopenia Due To Etmentioning
confidence: 76%
“…It is clear that the JAK2 V617F mutation presents not only in most MPN cases, but also some cases of AML, CML and myelodysplastic syndrome [10][11][12]; moreover, it has also been detected in patients with chronic lymphocytic leukemia (CLL). So far, 30 CLL patients have been reported to have the JAK2 V617F mutation, two of whom show no evidence of MPN [13]. Additional animal experimentation has also confirmed the crucial effect of the JAK2 gene in the development of B cell lymphoma/leukemia [14].…”
Section: Discussionmentioning
confidence: 92%
“…As of the date of this publication, only 28 JAK2 V617F-positive BCLL patients have been identified. 4 All of these patients exhibited a Ph negative MPN concomitantly. Although the coexistence of CLL and MPN has been only sporadically reported, a systematic study on this disease association has been published by Italian GIMEMA group.…”
Section: Discussionmentioning
confidence: 93%