Jaundice and Rash Associated with Chlorpropamide

Abstract

LETTERS AND COMMENTS rhabdomyolysis in the present case. Hypokalemia is an additional etiologic possibility, though at no time did the serum potassium significantly fall below normal during the hospitalization, and large replacement doses of potassium were not required. Although there are several possible explanations for rhabdomyolysis in patients with HNKC, the most likely explanation in uncomplicated cases such as this one is the effect of the hyperosmolarity on skeletal muscle. SummaryHNKC is a relatively common condition in older diabetic patients with numerous complications. Rhabdomyolysis is another complication of HNKC and should be suspected in these patients. Elevated CK levels should be recognized as a part of the syndrome.