Jerky spontaneous movements at term age in preterm infants who later developed cerebral palsy

Kanemaru, Nao; Watanabe, H.; Kihara, Hideki; Nakano, Hisako; Nakamura, Tomohiko; Nakano, Junji; Taga, Gentaro; Konishi, Y.

doi:10.1016/j.earlhumdev.2014.05.004

Cited by 40 publications

(33 citation statements)

References 29 publications

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“…There is now a growing interest in quantifying dynamic EMGs and kinematic patterns as predictive indicators of motor function in CP. For instance, the specific features of spontaneous movements provide useful information for predicting CP in very young infants (Hadders-Algra, 2014; Kanemaru et al, 2014). In spite of the existence of various classifications of early sensorimotor pathologies (Rosenbaum et al, 2014), detailed information about maturation of the spinal locomotor output in children with CP is much needed for both clinical diagnosis and assessment of the efficacy of gait rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Immature Spinal Locomotor Output in Children with Cerebral Palsy

et al. 2016

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Detailed descriptions of gait impairments have been reported in cerebral palsy (CP), but it is still unclear how maturation of the spinal motoneuron output is affected. Spatiotemporal alpha-motoneuron activation during walking can be assessed by mapping the electromyographic activity profiles from several, simultaneously recorded muscles onto the anatomical rostrocaudal location of the motoneuron pools in the spinal cord, and by means of factor analysis of the muscle activity profiles. Here, we analyzed gait kinematics and EMG activity of 11 pairs of bilateral muscles with lumbosacral innervation in 35 children with CP (19 diplegic, 16 hemiplegic, 2–12 years) and 33 typically developing (TD) children (1–12 years). TD children showed a progressive reduction of EMG burst durations and a gradual reorganization of the spatiotemporal motoneuron output with increasing age. By contrast, children with CP showed very limited age-related changes of EMG durations and motoneuron output, as well as of limb intersegmental coordination and foot trajectory control (on both sides for diplegic children and the affected side for hemiplegic children). Factorization of the EMG signals revealed a comparable structure of the motor output in children with CP and TD children, but significantly wider temporal activation patterns in children with CP, resembling the patterns of much younger TD infants. A similar picture emerged when considering the spatiotemporal maps of alpha-motoneuron activation. Overall, the results are consistent with the idea that early injuries to developing motor regions of the brain substantially affect the maturation of the spinal locomotor output and consequently the future locomotor behavior.

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Section: Introductionmentioning

confidence: 99%

Immature Spinal Locomotor Output in Children with Cerebral Palsy

et al. 2016

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“…In this way, the nest could have an impact on future motor and cognitive development at least up to 2 months of corrected age, as suggested by previous studies [13,[15][16][17][18][19].…”

Section: Nest and Abnormal Movementmentioning

confidence: 73%

“…Two other studies, conducted in preterm infants at term age, demonstrated that jerkiness of spontaneous movements at term age provides additional information for prediction of CP [18]. Likewise, spontaneous movements, less active with intermittent occurrences of limbs abrupt and synchronized movements, were associated with psychomotor delays at 3 years [19].…”

Section: Nest and Abnormal Movementmentioning

confidence: 95%

Posture and movement in very preterm infants at term age in and outside the nest

et al. 2015

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“…Kanemaru and coworkers, using reflective tape as limb sensors, found that children born preterm who exhibited developmental delay at 3 years of age, had less active spontaneous movements at termequivalent age (26). The video analysis in the present study is based on a sensor-less system to increase clinical feasibility.…”

Section: Discussionmentioning

confidence: 99%

“…Several methods for automated movement analysis have shown discriminative power with regard to later CP or other developmental delays in small groups of high-risk infants (25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%