Jnk Activation Is Accompanied By Ceramides And Diacylglycerol Accumulation In Isolated Hepatocytes

Кравченко, Г. А.; Krasilnikova, O. A.

doi:10.1016/j.atherosclerosis.2019.06.719

Cited by 2 publications

(1 citation statement)

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“…Moreover, elevated levels of Beclin1 could stem from the Beclin1-Bcl2 dissociation (147). In fact, ceramide triggers the JNK1 activation which leads to the phosphorylation of Bcl2 that in turn releases Beclin1 from the Beclin1-Bcl2 complex (148,149). Also, ceramide is involved in the activation of Forkhead box protein O3 (FOXO3) that can increase the expression levels of BNIP3 (150).…”

Section: Role Of Cers and Ceramides In Regulation Of Autophagymentioning

confidence: 99%

Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy

Alizadeh¹,

Rosa²,

Weng³

et al. 2023

Preprint

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Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides’ fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the development of new treatments to activate or inhibit a single type of ceramide synthase, thereby regulating the apoptosis induction or cross talk of apoptosis and autophagy in cancer cells. Moreover, the apoptotic function of ceramide suggests that ceramide analogues can pave the way for the development of novel cancer treatments. Therefore, in the current review paper we discuss the impact of ceramide synthases and ceramides in regulation of apoptosis and autophagy in context of different types of cancers. We also briefly introduce the latest methods to analyze the lipids in biological samples. Finally, we discuss the drug development strategies focusing on the ceramide synthases and ceramides as future therapeutic approaches in cancer therapy.

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Section: Role Of Cers and Ceramides In Regulation Of Autophagymentioning

confidence: 99%