Multiple‐Input Multiple‐Output Orthogonal Frequency Division Multiplexing (MIMO‐OFDM) is an essential technology in the wireless communication system. However, its performance is significantly affected by Carrier Frequency Offset (CFO), which leads to inter‐carrier interference (ICI). The CFO estimation and compensation techniques are used to mitigate the Doppler effect. In addition, the confidentiality of data is a key factor of the system. This paper proposes a Turbo‐based encryption and coding scheme to improve reliability and security for the MIMO‐OFDM wireless communication systems affected by the Doppler frequency offset. In our proposed scheme, the secret key is produced from channel parameters between legitimate users and it is used as a seed for generating a pseudo‐random bit sequence using an Advanced Encryption Standard (AES) generator with variable key lengths. The Turbo code's puncturing mechanism is controlled by this pseudo‐random bit sequence. The proposed method is applied to the system with different modulation schemes through the Rayleigh channel. The simulation results show that the system affected by the Doppler effect would obtain the best performance when using the highest key length of the AES generator, the BPSK, and a great number of receive antennas. Furthermore, the proposed solution outperforms several previous approaches for the MIMO‐OFDM systems.