JP-8 jet fuel-induced DNA damage in H4IIE rat hepatoma cells

Probability estimates for the unique childhood leukemia cluster in Fallon, Nevada, and risks near other U.S. Military aviation facilities.

“…Several studies have shown that JP-8 can affect immune system cells and may be genotoxic, although no clear link has been established with leukemia in humans or animals (Grant et al 2001;Harris et al 1997aHarris et al , 1997bHarris et al , 2000Harris et al , 2001Jackman et al 2002;Rhodes et al 2003;Ullrich 1999). Benzene has been associated with AML and possibly ALL in occupationally exposed cohorts (Hayes et al 2001;Savitz and Andrews 1997).…”

DEPSCoR 99 Percutaneous Absorption, Skin Biophysics and Dermatotoxicity from JP-8 Jet Fuel

“…Hence, it is less volatile and has a higher flash point than JP-4. JP-8 has been associated with toxicity in animal models and humans (Grant et al, 2000(Grant et al, , 2001Harris et al, 2000;Riviere et al, 1999;Robledo et al, 1999;Rosenthal et al, 2001;Singh and Singh, 2001a;Ulrich, 1999;Ulrich and Lyons, 2000). There is a great potential for human exposure to JP-8.…”

Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel

“…Studies on in vitro genotoxicity of jet fuel failed to demonstrate mutagenic eVects Nessel et al 1999;Vijayalaxmi et al 2006), whereas recent studies showed a signiWcant increase in DNA single-strand breaks in mammalian cells exposed in vitro and in vivo to petroleum derivatives, engine exhausts, and jet fuel, including Jet-A and JP-8 (Pitarque et al 1999;Grant et al 2001;Jackman et al 2002). The published data have demonstrated the formation of reactive oxygen species (ROS) during JP-8 treatment (Boulares et al 2002).…”