Jun, Fos and Krox in the hippocampus after noxious stimulation: simultaneous-input-dependent expression and nuclear speckling

Pearse, Damien D.; Mirza, A.; Leah, J.D.

doi:10.1016/s0006-8993(01)01993-x

Cited by 18 publications

(11 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, this type of sciatic electrical stimulation, when coupled with a weak noxious cutaneous stimulation applied to one hindpaw simultaneously, a significant induction of cFos did occur [180] . Noxious stimulation (single or combined) also resulted in different temporal patterns of other IEGs expression, reflecting cell type-dependent complex sequences of events initiated by the C-fiber input.…”

Section: Increase In C-fos Expression Following Painful Stimulation Imentioning

confidence: 69%

“…As introduced above, Pearse et al [180] ways in the central nervous system [183,184] . NK-1 receptors and BDNF have previously been implicated in nociceptioninduced spinal central sensitization [185][186][187] ; however, the effects of painful stimuli on the expression of these two genes in the mood/affect and emotion-processing brain regions have not yet been characterized.…”

Section: Egr1 Expression the Zinc Finger Transcription Factormentioning

confidence: 99%

“…There are mainly five papers, in our hands, reporting pain-evoked increase in c-Fos expression in the HF [165,[177][178][179][180] . Aloisi et al [177] investigated, by immunohistochemistry, the effects of a persistent painful stimulus (formalin injection) and restraint stress (immobilization) on cFos expression in the hippocampus and septum of male and female rats.…”

Section: Increase In C-fos Expression Following Painful Stimulation Imentioning

confidence: 99%

“…The fourth paper reporting pain-increased c-Fos expres- Krox-20 [180] . In the case of c-Fos, the authors observed that a brief, strong electrical stimulation of sciatic nerve C-fibers induced little or no expression of c-Fos in the hippocampus.…”

Section: Increase In C-fos Expression Following Painful Stimulation Imentioning

confidence: 99%

See 3 more Smart Citations

Roles of the hippocampal formation in pain information processing

2009

View full text Add to dashboard Cite

Abstract:Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchicallyinterconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation (HF) in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.

show abstract

Section: Increase In C-fos Expression Following Painful Stimulation Imentioning

confidence: 69%

Section: Egr1 Expression the Zinc Finger Transcription Factormentioning

confidence: 99%

Section: Increase In C-fos Expression Following Painful Stimulation Imentioning

confidence: 99%

Section: Increase In C-fos Expression Following Painful Stimulation Imentioning

confidence: 99%

See 2 more Smart Citations

Roles of the hippocampal formation in pain information processing

2009

View full text Add to dashboard Cite

show abstract

“…Subsequent studies confirmed a hippocampal role in pain processing (Lathe, 2001) using extracellular recordings (Zheng and Khanna, 1999), intracellular recordings (Wei et al, 2000), hippocampal EEG (Archer and Roth, 1997), in vivo microdialysis (Ceccarelli et al, 1999), immediateearly gene expression (Pearse et al, 2001), long-term potentiation (Wei et al, 2000), and functional neuroimaging (Hsieh et al, 1995;Derbyshire et al, 1997;Becerra et al, 1999;Casey, 1999;Peyron et al, 1999;Schneider et al, 2001). Wei et al (2000) demonstrated that the amplitude of EPSPs in hippocampal CA1 pyramidal cells is positively related to the intensity of nociceptive stimulation.…”

Section: Discussionmentioning

confidence: 92%

Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

et al. 2001

View full text Add to dashboard Cite

It is common clinical experience that anxiety about pain can exacerbate the pain sensation. Using event-related functional magnetic resonance imaging (FMRI), we compared activation responses to noxious thermal stimulation while perceived pain intensity was manipulated by changes in either physical intensity or induced anxiety. One visual signal, which reliably predicted noxious stimulation of moderate intensity, came to evoke low anxiety about the impending pain. Another visual signal was followed by the same, moderate-intensity stimulation on most of the trials, but occasionally by discriminably stronger noxious stimuli, and came to evoke higher anxiety. We found that the entorhinal cortex of the hippocampal formation responded differentially to identical noxious stimuli, dependent on whether the perceived pain intensity was enhanced by pain-relevant anxiety. During this emotional pain modulation, entorhinal responses predicted activity in closely connected, affective (perigenual cingulate), and intensity coding (midinsula) areas. Our finding suggests that accurate preparatory information during medical and dental procedures alleviates pain by disengaging the hippocampus. It supports the proposal that during anxiety, the hippocampal formation amplifies aversive events to prime behavioral responses that are adaptive to the worst possible outcome.

show abstract

Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats

Cho

Garg

et al. 2009

J of Comparative Neurology

111

View full text Add to dashboard Cite

Hypothermia has been employed during the past 30 years as a therapeutic modality for spinal cord injury (SCI) in animal models and in humans. With our newly developed rat cervical model of contusive SCI, we investigated the therapeutic efficacy of transient systemic hypothermia (beginning 5 minutes post-injury for 4 hours, 33 degrees C) with gradual rewarming (1 degrees C per hour) for the preservation of tissue and the prevention of injury-induced functional loss. A moderate cervical displacement SCI was performed in female Fischer rats, and behavior was assessed for 8 weeks. Histologically, the application of hypothermia after SCI resulted in significant increases in normal-appearing white matter (31% increase) and gray matter (38% increase) volumes, greater preservation (four-fold) of neurons immediately rostral and caudal to the injury epicenter, and enhanced sparing of axonal connections from retrogradely traced reticulospinal neurons (127% increase) compared with normothermic controls. Functionally, a faster rate of recovery in open field locomotor ability (BBB score, weeks 1-3) and improved forelimb strength, as measured by both weight-supported hanging (43% increase) and grip strength (25% increase), were obtained after hypothermia. The current study demonstrates that mild systemic hypothermia is effective for retarding tissue damage and reducing neurological deficits following a clinically relevant contusive cervical SCI.

show abstract

Jun, Fos and Krox in the hippocampus after noxious stimulation: simultaneous-input-dependent expression and nuclear speckling

Cited by 18 publications

References 92 publications

Roles of the hippocampal formation in pain information processing

Roles of the hippocampal formation in pain information processing

Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats

Contact Info

Product

Resources

About