Junctional Complexes in the Early Mammalian Embryo

Fleming, Tom P.; Ghassemifar, Reza; Sheth, Bhavwanti

doi:10.1055/s-2000-12557

Cited by 62 publications

(55 citation statements)

References 76 publications

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“…At this stage, desmosomes are present in the trophectoderm (TE), a single-layered polarized epithelium that forms the outer cell layer of the embryo (Fleming et al, 2000;Jackson et al, 1980). As shown in Fig.…”

Section: Dsc3 Is Expressed Throughout Embryogenesismentioning

confidence: 99%

“…During this process, individual embryonic cells (blastomeres) activate cell-cell adhesion proteins, in particular E-cadherin and associated catenins (Blaschuk et al, 1990;Larue et al, 1994;Ohsugi et al, 1996;Ohsugi et al, 1997;Pauken and Capco, 1999;Riethmacher et al, 1995;Torres et al, 1997). As a consequence, blastomeres begin to polarize and assemble the first cell junctions (reviewed by Fleming et al, 2000;Gallicano, 2001). This process turns the loose aggregate of blastomeres into a compact sphere.…”

Section: Dsc3mentioning

confidence: 99%

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Desmocollin 3 is required for pre-implantation development of the mouse embryo

Den

Cheng

Merched-Sauvage

et al. 2006

Journal of Cell Science

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Desmocollin 3 (Dsc3) is a transmembrane glycoprotein that belongs to the cadherin family of cell adhesion receptors. Together with desmoglein(s), it forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Previous reports have suggested that Dsc3 synthesis is largely restricted to stratified epithelia, and that it plays a role in the proper differentiation of these tissues during mammalian embryonic development. To test these hypotheses, we generated Dsc3-null mice. Unexpectedly, homozygous mutants show a pre-implantation lethal phenotype. In fact, most mutants die even before mature desmosomes are formed in the embryo, suggesting a new and unexpected role of Dsc3 during early development.

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Section: Dsc3 Is Expressed Throughout Embryogenesismentioning

confidence: 99%

Section: Dsc3mentioning

confidence: 99%

Desmocollin 3 is required for pre-implantation development of the mouse embryo

Den

Cheng

Merched-Sauvage

et al. 2006

Journal of Cell Science

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“…In other mammals and human, biochemical studies have also identified regulation of connexin expression during development (Bloor et al, 2004;Fl echon et al, 2004). GJ have been shown to play a basic role on embryo viability (Fleming et al, 2000); however, how they are able to regulate normal growth of the embryo remains an open question. Contrasting literature data arise on functional requirements for GJ in pre-implantation development (see Houghton, 2005 for review).…”

Section: Gap Junction Channels In Embryo Developmentmentioning

confidence: 99%

Ion currents in embryo development

Tosti

Boni

Gallo

2016

Birth Defects Research Pt C

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Ion channels are proteins expressed in the plasma membrane of electrogenic cells. In the zygote and blastomeres of the developing embryo, electrical modifications result from ion currents that flow through these channels. This phenomenon implies that ion current activity exerts a specific developmental function, and plays a crucial role in signal transduction and the control of embryogenesis, from the early cleavage stages and during growth and development of the embryo. This review describes the involvement of ion currents in early embryo development, from marine invertebrates to human, focusing on the occurrence, modulation, and dynamic role of ion fluxes taking place on the zygote and blastomere plasma membrane, and at the intercellular communication between embryo cell stages.Birth Defects Research (Part C) 108:6-18, 2016.V C 2016 Wiley Periodicals, Inc.

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“…Compaction is signaled by an increase in cell-to-cell contact between embryonic blastomeres. It is driven by the establishment of adherens junctions consisting of E-cadherin and catenin complexes (Fleming et al 2000, Johnson & McConnell 2004. Compaction is initiated at the eight-cell stage in the mouse but the timing varies across species (Telford et al 1990).…”

Section: Compaction and Cell Polaritymentioning

confidence: 99%

“…Compaction is initiated at the eight-cell stage in the mouse but the timing varies across species (Telford et al 1990). In all cases, it results in the formation of a morula by which the 16-cell stage in the mouse creates a topology that forms outer and inner cells that are completely surrounded by the outer cells (Fleming et al 2000, Johnson & McConnell 2004. These cell types are the progenitors of the TE and ICM.…”

Section: Compaction and Cell Polaritymentioning

confidence: 99%

Preimplantation embryo programming: transcription, epigenetics, and culture environment

Duranthon¹,

Watson²,

Lonergan³

2008

Reproduction

104

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Preimplantation development directs the formation of an implantation-or attachment-competent embryo so that metabolic interactions with the uterus can occur, pregnancy can be initiated, and fetal development can be sustained. The preimplantation embryo exhibits a form of autonomous development fueled by products provided by the oocyte and also from activation of the embryo's genome. Despite this autonomy, the preimplantation embryo is highly influenced by factors in the external environment and in extreme situations, such as those presented by embryo culture or nuclear transfer, the ability of the embryo to adapt to the changing environmental conditions or chromatin to become reprogrammed can exceed its own adaptive capacity, resulting in aberrant embryonic development. Nuclear transfer or embryo culture-induced influences not only affect implantation and establishment of pregnancy but also can extend to fetal and postnatal development and affect susceptibility to disease in later life. It is therefore critical to define the basic program controlling preimplantation development, and also to utilize nuclear transfer and embryo culture models so that we may design healthier environments for preimplantation embryos to thrive in and also minimize the potential for negative consequences during pregnancy and post-gestational life. In addition, it is necessary to couple gene expression analysis with the investigation of gene function so that effects on gene expression can be fully understood. The purpose of this short review is to highlight our knowledge of the mechanisms controlling preimplantation development and report how those mechanisms may be influenced by nuclear transfer and embryo culture.

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Junctional Complexes in the Early Mammalian Embryo

Cited by 62 publications

References 76 publications

Desmocollin 3 is required for pre-implantation development of the mouse embryo

Desmocollin 3 is required for pre-implantation development of the mouse embryo

Ion currents in embryo development

Preimplantation embryo programming: transcription, epigenetics, and culture environment

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