Juvenile phyllodes tumor of the breast

Prihantono, Prihantono; Satria, Bayu

doi:10.1016/j.epsc.2020.101448

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…3 These tumors have an incidence of only 0.1% of all breast neoplasms, most commonly occurring in women ages 40-50, with few cases reported among adolescents. 4,5 PTs often present as a mobile breast mass with rapid growth. Initial investigation requires multi-modal approaches with clinical and radiologic examination, tissue biopsy, and subsequent excision for definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Immediate Breast Reconstruction in an 11-year-old Girl with a Large Malignant Phyllodes Tumor

Serhan¹,

Kemp²

2022

Plastic and Reconstructive Surgery - Global Open

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Summary: Phyllodes tumors are rare fibroepithelial breast tumors representing less than 1% of all breast malignancies, with an extremely uncommon presence in the pediatric population.1 Although prognosis is favorable following excision given their indolent course, they often grow rapidly and frequently recur. As such, they can present unique oncologic and reconstructive challenges. Herein we present a case of a malignant phyllodes tumor in an 11-year-old girl treated with total skin-sparing mastectomy and adjustable saline implant, and explore the reconstructive challenges of this unique case.

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Section: Discussionmentioning

confidence: 99%

“…9 A positive margin in malignant PT requires immediate return to surgery for re-excision. 1,5 There is controversy regarding adjuvant radiotherapy and chemotherapy, as the benefits of these therapies are unclear. 10 A review of the literature reveals only 20 published cases of PTs in adolescents.…”

Section: Discussionmentioning

confidence: 99%

Immediate Breast Reconstruction in an 11-year-old Girl with a Large Malignant Phyllodes Tumor

Serhan¹,

Kemp²

2022

Plastic and Reconstructive Surgery - Global Open

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“…The ages of subjects in this study varied with a range of 26–66 years and most being aged 50–60 years (41.9%). A study by the American Cancer Society found 231,840 new cases of invasive breast cancer in women within the United States in 2015, and the most vulnerable group (59,990 cases) was those aged 60–69 years old [ 2 , 22 , 23 ]. Most breast cancer patients in Indonesia that come for treatment are usually in the advanced stages, and 63% are in stages III and IV at diagnosis [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

The relationship between NFKB, HER2, ER expression and anthracycline -based neoadjuvan chemotherapy response in local advanced stadium breast cancer: A cohort study in Eastern Indonesia

Manginstar

Islam

Sampepajung

et al. 2021

Annals of Medicine &Amp; Surgery

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Introduction Neoadjuvant chemotherapy has become the standard form of treatment for locally advanced breast cancer. Chemoresistence is a problem that limits the effectiveness of chemotherapy. Therefore, predictive biomarkers are needed to choose the appropriate chemotherapy to the right patient. The role of NF-кb expression as a predictive biomarker of neoadjuvant chemotherapy response needs to be investigated in patients with locally advanced breast cancer who are treated with a regimen of cyclophosphamide-doxorubicin-5FU (CAF). Methods This observational study used the prospective cohort method to examine 62 samples. CAF was administered at 3-week intervals for 3 cycles of chemotherapy. The data utilized in this study include the positive and negative expression of NF-κB, ER, and HER2 overexpression. The cases were divided into groups that were responsive and non-responsive to the neoadjuvant chemotherapy. Results The average age in the youngest group was 26 years, and that in the oldest was 66 years. The highest age group was subjects in their 50s, which had 26 cases (41.9%). The majority of the cases were moderate grade with 38 cases (61.3%). The percentage of responsive subjects was higher in the groups with negative NF-κB expression (82.5%), positive HER2 status (85.7%), and negative ER status (71.9%). It was found that 37 cases (59.7%) were responsive to CAF, while 25 cases (40.3%) were non-responsive. There was a significant relationship between NF-κB expression and chemotherapy response (p < 0.05), and the percentage of responsive subjects was higher among those with negative NF-κB expression (82.5%) than positive NF-κB expression (18.2%). Conclusion NF-κB expression, ER status, and HER2 have a significant relationship with the response to anthracycline-based neoadjuvant chemotherapy for local advanced breast cancer, and NF-κB expression has the most significant relationship with the chemotherapy response. Therefore, NF-κB expression should be considered as a predictive biomarker for the response to CAF regimens.

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“…Out of the several congenital, inflammatory, and neoplastic lesions, phyllodes tumor or cystosarcoma phyllodes accounts for 0.3-0.5% of tumors [1], with the majority of them being benign. In 1838, Johannes Muller described it as a tumor with a fleshy, greyish white, leaf-like mass, hence the name phyllodes (phyllos -leaf, Greek) [2]. However, in 1982, WHO declared "phyllodes" as the most appropriate term out of the other 60 synonyms of the lesion [3].…”

Section: Introductionmentioning

confidence: 99%

“…However, in 1982, WHO declared "phyllodes" as the most appropriate term out of the other 60 synonyms of the lesion [3]. It is commonly noted in the third to fourth decades of life at an incidence of 2.1 per million [2,3], out of which, cases of adolescent, premenarchal females in the bilateral breast are negligible, i.e. less than 0.1%.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Phyllodes in a 12-Year-Old Adolescent: Report of a Rare Case

Kenjale¹,

Dighe²,

Shinde³

et al. 2022

Cureus

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Phyllodes tumors, previously known as cystosarcoma phyllodes, are fibroepithelial tumors that consist of epithelial and cellular stromal components. These tumors have a predilection to recur after wide local excision and to attain massive sizes. They account for less than 0.5% of cases of all breast neoplasms and are primarily found in the third to fourth decade of life, and rarely in adolescence. However, less than 25 cases are reported to date wherein this tumor is found in adolescent females, with this case being one of those. This is a report of a rare case of a 12-year-old premenarchal female with bilateral phyllodes tumor, highlighting its peculiarities, diagnostic features, and surgical management in view of the patient's age and quality of life.

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Juvenile phyllodes tumor of the breast

Cited by 6 publications

References 14 publications

Immediate Breast Reconstruction in an 11-year-old Girl with a Large Malignant Phyllodes Tumor

Immediate Breast Reconstruction in an 11-year-old Girl with a Large Malignant Phyllodes Tumor

The relationship between NFKB, HER2, ER expression and anthracycline -based neoadjuvan chemotherapy response in local advanced stadium breast cancer: A cohort study in Eastern Indonesia

Bilateral Phyllodes in a 12-Year-Old Adolescent: Report of a Rare Case

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