Juxtaglomerular cell tumor: A case report

Abstract

Abstract. The current study reports the case of a 29-year-old female with a long-standing history of hypertension and headaches who presented to the Outpatient Clinic of The Central Hospital of Lishui (Lishui, Zhejiang, China). Abdominal ultrasound and contrast-enhanced computed tomography were performed, which showed a left renal neoplasm, prompting a diagnosis of renal angiomyolipoma or renal cell carcinoma. After a laparoscopic partial nephrectomy was performed, a number of different diagnoses were suggested by several pathologists from eight hospitals. Considering the patient's gender, age, medical history, histopathological features and immunohistochemistry, a final diagnosis of a juxtaglomerular cell tumor (JGCT) was established. The present study therefore indicates that the possibility of a JGCT should be considered when young adults present with renal parenchymatous tumors and high blood pressure. In addition, pathologists must take clinical information into account to form a precise diagnosis.

Juxtaglomerular Cell Tumor With Atypical Pathological Features: Report of a Case and Review of Literature

“…JGCT occurs mostly in young adults. The peak age of incidence is in the second and third decades, 4 with the age at diagnosis ranging from 6 years to 72 years. 5 There is a female predominance.…”

“…The weak positivity for synaptophysin was unusual, but has been previously reported. 4,17 Renin immunohistochemistry was not performed. It is important to note that some other tumors can secrete renin, including renal cell carcinoma, Wilms tumor, congenital mesoblastic nephroma, hepatoblastoma, lung carcinoma, ovarian tumor, soft tissue tumors, and glioblastoma multiforme 8 .…”

Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report

“…JGCT affects predominantly women, with a female-to-male ratio of 1.8:1 [ 17 ]. The tumor is mostly diagnosed in the second or third decade of life [ 18 ], with the age of diagnosis ranging from 6 to 72 years [ 19 ]. Reninomas generally have a benign character, and there have been just three reported cases with malignant features.…”

Vascular Neoplasms and Related Lesions of Kidney

“…MRI of JGCTs usually demonstrates isointensity on T1-weighted images and variable hyperintensity on T2-weighted images with mild heterogeneous contrast enhancement [100,103]. Overall the imaging features of JGCTs are largely non-specific and cannot be distinguished from other solid renal neoplasms [104].…”

“…On ultrasonography, JGCT appears as a solid hypoechoic mass [103,104]. CT studies typically show a well-circumscribed, isoattenuating to hypoattenuating cortical-based tumor without significant enhancement on contrast administration; the findings may raise suspicion for RCC or angiomyolipoma, or in the case of isodense non-enhancing tumors, may go completely undetected on CT imaging [100,[103][104][105]. MRI of JGCTs usually demonstrates isointensity on T1-weighted images and variable hyperintensity on T2-weighted images with mild heterogeneous contrast enhancement [100,103].…”