JWA deficiency induces malignant transformation of murine embryonic fibroblast cells

Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery

“…Vimentin and β-catenin protein expressions were up-regulated in JWA −/− MEF cells, whereas Ecadherin protein expression levels were down-regulated. JWA may mediate cell migration by regulating the expression of epithelial-mesenchymal transition-related proteins [84]. Therefore, JWA suppresses metastasis involving multiple signaling pathways, including inhibition of receptor-dependent (HER2 and CXCR4) PI3K/AKT activation, regulation of microfilament depolymerization and reorganization, and inhibition of the EMT process (Figure 3C).…”

“…JWA can be used as a novel regulator of XRCC1 in the BER protein complex to promote DNA SSB repair [110]. In addition, in the process of malignant transformation of MEF cells using JWA knockdown, JWA knockdown causes the upregulation of poly (ADP-ribose) polymerase 1 (PARP1) repair protein and changes in EMT-related proteins, indicating that JWA plays a similar function as a tumor suppressor protein in the process of tumorigenesis [84]. In addition, deletion of JWA in mice aggravates 7,12-dimethylbenz(a)anthracene (DMBA)-induced DNA damage, resulting in more severe genomic instability [111].…”