K003 Modelisation physiologique integrative de la regulation de la pression arterielle et du systeme renine-angiotensine circulant

Guillaud, François; Hannaert, P.

doi:10.1016/s1875-2136(09)72406-4

Cited by 2 publications

(2 citation statements)

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“…The most common suffix for these medications is “-pril.” Some of the examples are lisinopril, ramipril, and captopril. According to the chemical composition, it is divided into three groups: sulfhydryl-containing ACE inhibitor (captopril), phosphorus-containing ACE inhibitor (fosinopril), and dicarboxylic-containing ACE inhibitors (benazepril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril) [ 44 ]. ACE inhibitors are a class of medicines that are used for the treatment of distinct disorders and are the first-class alternative for cardiovascular disease treatment [ 45 ].…”

Section: Angiotensin-converting Enzyme (Ace)mentioning

confidence: 99%

Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension

Khan

Haque

Ahmad

et al. 2023

J Renin Angiotensin Aldosterone Syst

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Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal infection, and cardiovascular diseases. Many mechanisms are involved in causing hypertension, i.e., via calcium channels, alpha and beta receptors, and the renin-angiotensin system (RAS). RAS has an important role in blood pressure control and is also involved in the metabolism of glucose, homeostasis, and balance of electrolytes in the body. The components of RAS that are involved in the regulation of blood pressure are angiotensinogen, Ang I (angiotensin I), Ang II (angiotensin II), ACE (angiotensin-converting enzyme), and ACE 2 (angiotensin-converting enzyme 2). These components provide for relevant therapeutic targets for the treatment of hypertension, and various drugs are commercially available that target individual components of RAS. Angiotensin receptor blockers (ARBs) and ACE inhibitors are the most popular among these drugs. ACE is chosen in this review as it makes an important target for blood pressure control because it converts Ang I into Ang II and also acts on the vasodilator, bradykinin, to degrade it into inactive peptides. This review highlights various aspects of blood pressure regulation in the body with a focus on ACE, drugs targeting the components involved in regulation, their associated side effects, and a need to shift to alternative therapy for putative hypertension treatment in the form of bioactive peptides from food.

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Section: Angiotensin-converting Enzyme (Ace)mentioning

confidence: 99%

Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension

Khan

Haque

Ahmad

et al. 2023

J Renin Angiotensin Aldosterone Syst

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“…The rate of catalysis of Ang II by ACE2 enzyme is 400-fold that of Ang I; Ang II is considered the main substrate of the ACE2, so the main function of ACE2 is to transform Ang II to Ang1-7 [99, 101, 102]. Therefore, ACE2 plays a key role in the equilibrium between the two axes of vasoconstrictor (ACE/Ang II/AT1R) and vasodilator (ACE2/Ang 1-7/MasR) of RAS [103, 104]. Although renin is the limiting rate in the formation of Ang II as the primary mediator of RIRI, ACE2 through the breakdown of Ang II to Ang 1-7 plays an important role in determining the level of tissue Ang II and therefore RIRI [84, 105].…”

Section: The View Of Nonconventional Ras In Akimentioning

confidence: 99%

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury

Karimi¹,

Maleki

Nematbakhsh

2022

J Renin Angiotensin Aldosterone Syst

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Renal ischemia-reperfusion injury (RIRI) is a sequence of complicated events that is defined as a reduction of the blood supply followed by reperfusion. RIRI is the leading cause of acute kidney injury (AKI). Among the diverse mediators that take part in RIRI-induced AKI, the renin-angiotensin system (RAS) plays an important role via conventional (angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptor (AT1R)) and nonconventional (ACE2, Ang 1-7, Ang 1-9, AT2 receptor (AT2R), and Mas receptor (MasR)) axes. RIRI alters the balance of both axes so that RAS can affect RIRI-induced AKI. In overall, the alteration of Ang II/AT1R and AKI by RIRI is important to consider. This review has looked for the effects and interactions of RAS activities during RIRI conditions.

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K003 Modelisation physiologique integrative de la regulation de la pression arterielle et du systeme renine-angiotensine circulant

Cited by 2 publications

References 0 publications

Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension

Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury

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