Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE‐19 cells

Chien, Hsiang-Wen; Wang, Kai; Chang, Yuan Yen; Hsieh, Yi‐Hsien; Yu, Nuo-Yi; Yang, Shun‐Fa; Lin, Hui-Wen

doi:10.1002/tox.22686

Cited by 22 publications

(20 citation statements)

References 35 publications

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“…Induced cell cycle arrest at the G2/M or G0/G1 phase [329,[335][336][337][338][339][340]. Reduced migration and invasion [340][341][342][343][344][345][346]. Inhibited the EMT and reduced resistance to chemotherapeutic agents [343,347].…”

Section: Kaempferolmentioning

confidence: 99%

“…Kaempferol exhibited anti-proliferative effects in endometrial carcinoma cells through apoptosis and cell cycle arrest, and was able to decrease migration and invasion trends in these cells [340]. In immortalized human retinal pigment epithelial (ARPE-19) cells, treatment with kaempferol was able to decrease cell migration through ERK1/2 signaling [346]. Kaempferol-conjugated gold nanoclusters (K-AuNCs) were developed by Govindaraju et al [424] as a potential anti-cancer drug delivery system, and they demonstrated that K-AuNCs targeted A549 lung cancer cells and exhibited toxicity via nucleus damage.…”

Section: Kaempferolmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

160

139

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In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

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Section: Kaempferolmentioning

confidence: 99%

Section: Kaempferolmentioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

160

139

View full text Add to dashboard Cite

show abstract

“…Moreover, kaempferol inhibited metastasis of 786-O cells into the lungs by 87.4% in the SCID mice model [ 81 ]. In addition, kaempferol suppressed migration and invasion of ARPE-19 human retinal pigment epithelial cells via the reduction of protein expression and activity of MMP-2 mediated by increased levels of phosphorylated extracellular signal-regulated kinases 1/2 ERK1/2 [ 82 ].…”

Section: Targeting Metastatic Cancermentioning

confidence: 99%

Flavonoids in Cancer Metastasis

Líšková

Koklesová

Samec

et al. 2020

Cancers

137

128

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Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various health beneficiary effects. The effects of flavonoids against cancer are associated not only with early stages of the cancer process, but also with cancer progression and spread into distant sites. Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-β and other contributors of the complex process of metastatic spread. Moreover, flavonoids modulated also the expression of genes associated with the progression of cancer and improved inflammatory status, a part of the complex process involved in the development of metastasis. Flavonoids also documented clear potential to improve the anti-cancer effectiveness of conventional chemotherapeutic agents. Most importantly, flavonoids represent environmentally-friendly and cost-effective substances; moreover, a wide spectrum of different flavonoids demonstrated safety and minimal side effects during long-termed administration. In addition, the bioavailability of flavonoids can be improved by their conjugation with metal ions or structural modifications by radiation. In conclusion, anti-cancer effects of flavonoids, targeting all phases of carcinogenesis including metastatic progression, should be implemented into clinical cancer research in order to strengthen their potential use in the future targeted prevention and therapy of cancer in high-risk individuals or patients with aggressive cancer disease with metastatic potential.

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“…Kaempferol has been shown to suppress migration and invasion in many cancers [ 5 , 13 , 14 , 23 ]. For instance, kaempferol inhibits the migration and invasion of human retinal pigment epithelial cells [ 24 ]. Recent studies have shown that kaempferol represses migration and invasion via various signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Effect and mechanisms of kaempferol against endometriosis based on network pharmacology and in vitro experiments

Zhao

Wang

Liu

et al. 2022

BMC Complement Med Ther

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Endometriosis is a common gynecological disease, and its underlying mechanisms remain elusive. Patients are at a higher risk of recurrence after surgery or drug withdrawal. In this study, to identify a potentially effective and safe therapy for endometriosis, we screened potential target genes of kaempferol on endometriosis using network pharmacology and further validation. Network pharmacology showed kaempferol may suppress migratory and invasive properties by modulating the phosphoinositide 3-kinase (PI3K) pathway and its downstream target matrix metalloproteinase (MMP)9. Furthermore, in vitro experiments showed that kaempferol repressed the migration and invasion of endometrial cells, and this effect may be involved in mediating the PI3K-related genes, phosphatase and tensin homolog (PTEN) and MMP9. Network pharmacology and in vitro experiments showed that kaempferol, repressed the implantation of endometrial cells and formation of ectopic lesions by inhibiting migration and invasion and regulating PTEN and MMP9, which may be associated with the PI3K pathway.

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Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE‐19 cells

Cited by 22 publications

References 35 publications

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Flavonoids in Cancer Metastasis

Effect and mechanisms of kaempferol against endometriosis based on network pharmacology and in vitro experiments

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