Kaempferol therapy improved MC903 induced-atopic dermatitis in a mouse by suppressing TSLP, oxidative stress, and type 2 inflammation

Nasanbat, Bolor; Uchiyama, Akihiko; Amalia, Syahla Nisaa; Inoue, Yuta; Yokoyama, Yoko; Ogino, Sachiko; Torii, Ryoko; Hosoi, Mari; Motegi, Sei‐ichiro

doi:10.1016/j.jdermsci.2023.06.008

Cited by 11 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the kaempferol content in American ginseng leaves reached the highest value after FIR treatment at 190 • C, its content in ginseng leaves was different, and it stopped increasing after FIR treatment at 180 • C. This could have been caused by the different compositions and amounts of panasenoside in the raw material used. Kaempferol (a deglycosylation product) has high anti-inflammatory [2], antitumor [3], and antioxidant activities [38]. According to the above experimental results, it can be concluded that the kaempferol content in American ginseng leaves was markedly increased by FIR treatment at 190 • C.…”

Section: The Effect Of Fir Heat Treatment On the Amounts Of Panasenos...mentioning

confidence: 87%

Increasing the Amounts of Bioactive Components in American Ginseng (Panax quinquefolium L.) Leaves Using Far-Infrared Irradiation

Wang,

Kim,

Han

et al. 2024

Foods

View full text Add to dashboard Cite

Both the roots and leaves of American ginseng contain ginsenosides and polyphenols. The impact of thermal processing on enhancing the biological activities of the root by altering its component composition has been widely reported. However, the effects of far-infrared irradiation (FIR), an efficient heat treatment method, on the bioactive components of the leaves remain to be elucidated. In the present study, we investigated the effects of FIR heat treatment between 160 and 200 °C on the deglycosylation and dehydration rates of the bioactive components in American ginseng leaves. As the temperature was increased, the amounts of common ginsenosides decreased while those of rare ginsenosides increased. After FIR heat treatment of American ginseng leaves at an optimal 190 °C, the highest total polyphenolic content and kaempferol content were detected, the antioxidant activity was significantly enhanced, and the amounts of the rare ginsenosides F4, Rg6, Rh4, Rk3, Rk1, Rg3, and Rg5 were 41, 5, 37, 64, 222, 17, and 266 times higher than those in untreated leaves, respectively. Moreover, the radical scavenging rates for 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) and the reducing power of the treated leaf extracts were 2.17, 1.86, and 1.77 times higher, respectively. Hence, FIR heat treatment at 190 °C is an efficient method for producing beneficial bioactive components from American ginseng leaves.

show abstract

Section: The Effect Of Fir Heat Treatment On the Amounts Of Panasenos...mentioning

confidence: 87%

Increasing the Amounts of Bioactive Components in American Ginseng (Panax quinquefolium L.) Leaves Using Far-Infrared Irradiation

Wang,

Kim,

Han

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…It reduces Interleukin 4 and Interleukin 13 expression, inhibiting inflammation in specific dermatitis mouse models. 27 In gouty arthritis models, 28 Kae inhibits Transforming Growth Factor-β1, IL-1β, IL-6, and TNF-α, reducing ankle edema and inflammation. Kae also mitigates neurotoxic effects induced by bupivacaine in dorsal root ganglia, deactivating TNF Receptor Related Factor 6 (TRAF6)/ NF-κB signaling and reducing IL-6, IL-1β, and TNF-α levels.…”

Section: Discussionmentioning

confidence: 99%

Mechanism and Experimental Verification of Rhodiola rosea L. for the Treatment of Acute Lung Injury Through Network Pharmacology and Molecular Docking

Zhao,

Lv,

Huang

et al. 2024

Natural Product Communications

View full text Add to dashboard Cite

Objective: This article endeavors to dissect the bioactive elements, pharmacological effects, and potential mechanisms of Rhodiola rosea L. (RL) concerning acute lung injury (ALI) using a combined approach of network pharmacology and subsequent in vivo experimental validation. Methods: RL constituents and associated targets were retrieved from the Organchem database and pertinent articles. ALI-related targets were meticulously curated through comprehensive searches of GeneCards, OMIM, and DisGeNET databases. Utilizing Cytoscape 3.8.2 software, an intricate RL-ALI ingredients-targets network diagram was fashioned. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted using the Metascape database and microbiota software to unravel the functional and pathway implications of the identified interactions. AutoDock Vina and PyMOL were used to conduct molecular docking. Subsequently, the ALI rats were established by intraperitoneal injection of lipopolysaccharide (LPS) into Sprague Dawley rats, the potential mechanism for treating ALI was validated by kaempferol. Results: 18 active components of RL for ALI were screened, which were related to 306 targets of RL for ALI. Kaempferol (Kae) was a potential major component of ALI treatment. Molecular docking showed Kae had good binding ability to Epidermal Growth Factor Receptor (EGFR), nonreceptor tyrosine kinase, and serine/threonine kinase 1. In addition, at the animal level, Kae alleviated ALI by inhibiting the production of inflammatory cytokines. Lung tissue sections of the Kae-treated group at different doses showed reduced bleeding and reduced exudation of inflammatory factors compared to the LPS cohort. Compared with the LPS group, the secretion of Interleukin-6, tumor necrosis factor-alpha, and Phosphorylated Epidermal Growth Factor Receptor was significantly decreased in the Kae group, while the content of Phosphorylated Protein Kinase B was increased, and the lung injury was alleviated. Conclusion: Through network pharmacology and experimental verification, we identified Kae as the main active ingredient. Kae may reduce the expression of inflammatory factors and regulate the EGFR-AKT signaling pathway, subsequently exerting therapeutic effects in the treatment of ALI.

show abstract

“…Recently, Kaempferol, a flavonoid identified in various dietary sources, has been reported to alleviate symptoms of AD via suppression of type 2 inflammation and improvement of barrier dysfunction by inhibition of TSLP expression and oxidative stress [55]. Furthermore, it has been demonstrated to prevent intestinal inflammation and modulate gut microbiota in mice fed a high-fat diet [56], which may link AD and IBD through the lens of dietary components and intestinal microbiota.…”

Section: Crohn's Disease (Cd) and Ulcerative Colitis (Uc)mentioning

confidence: 99%

Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review

Zysk,

Mesjasz,

Trzeciak

et al. 2024

IJMS

View full text Add to dashboard Cite

The current understanding of atopic dermatitis (AD) seems to be extending beyond a skin-confined condition frequently associated with allergic comorbidities, as in a number of epidemiological studies, the prevalence rate of a range of illnesses has been determined to be greater in patients with AD, or inversely. In most cases, the reasons for this are vague. A subset of these conditions are gastrointestinal disorders, including food sensitization (FS) and food allergy (FA), eosinophilic esophagitis (EoE) (it is of mixed background, both IgE-dependent and independent), food protein-induced enterocolitis syndrome (FPIES) (it exemplifies an IgE-independent food allergy), Crohn’s disease (CD), colitis ulcerosa (CU), celiac disease, irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD). In this review, we performed a comprehensive search of the literature using the PubMed database. We addressed the epidemiology of the increased co-occurrence of these diseases with AD and discussed potential causes for this subject. Multiple gastroenterological comorbidities appear to be more common in patients with AD, according to our review. The mechanisms that underlie this phenomenon are largely unknown, highlighting the need for further study in this field.

show abstract

Kaempferol therapy improved MC903 induced-atopic dermatitis in a mouse by suppressing TSLP, oxidative stress, and type 2 inflammation

Cited by 11 publications

References 46 publications

Increasing the Amounts of Bioactive Components in American Ginseng (Panax quinquefolium L.) Leaves Using Far-Infrared Irradiation

Increasing the Amounts of Bioactive Components in American Ginseng (Panax quinquefolium L.) Leaves Using Far-Infrared Irradiation

Mechanism and Experimental Verification of Rhodiola rosea L. for the Treatment of Acute Lung Injury Through Network Pharmacology and Molecular Docking

Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review

Contact Info

Product

Resources

About