Kahalalides:  Bioactive Peptides from a Marine Mollusk <i>Elysia rufescens</i> and Its Algal Diet <i>Bryopsis</i> sp

Hamman, Mark T.; Otto, Clifton S; Scheuer, Paul J.; Dunbar, D. Chuck

doi:10.1021/jo984009j

Cited by 9 publications

(9 citation statements)

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“…106 Both compounds exhibited activity towards M. smegmatis with MIC values of 1.56 and 3.13 µg ml Ϫ1 , in addition to being cytotoxic with IC 50 0.15-1.06 µg ml Ϫ1 . The final example of an antimycobacterial anthraquinone analogue is nothramicin (125), also isolated from a fermentation of a species of pathogenic Nocardia. 107 Nothramicin exhibited MIC values of 1.56 µg ml Ϫ1 (M. smegmatis), 6.25 µg ml Ϫ1 (against a variety of drug resistant strains of M. smegmatis), 6.25 µg ml Ϫ1 (M. phlei), 12.5 µg ml Ϫ1 (M. vaccae) and 25 µg ml Ϫ1 (M. fortuitum).…”

Section: Alkanes Alkenes Alkynes and Simple Aromaticsmentioning

confidence: 99%

Antimycobacterial natural products

Copp

2003

Nat. Prod. Rep.

186

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This review covers the literature published between January 1990 and December 2002 (inclusive) for natural products with reported antimycobacterial activity, with 248 citations to 352 compounds isolated from both terrestrial and marine sources The compounds are presented in order of chemical type, namely lipids/fatty acids and simple aromatics phenolics and acetogenic quinones, peptides, alkaloids, terpenes (monoterpenoids, diterpenes, sesquiterpenes, sesterterpenes and triterpenes) and steroids.

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Section: Alkanes Alkenes Alkynes and Simple Aromaticsmentioning

confidence: 99%

Antimycobacterial natural products

Copp

2003

Nat. Prod. Rep.

186

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“…The kahalalides are a family of several structurally unrelated depsipeptides [60][61][62][63][64][65]. These compounds were isolated from a sacoglossan mollusk Elysia rufescens, whose diet includes a green alga, Bryopsis sp.…”

Section: Kakalalidesmentioning

confidence: 99%

Recent Developments in Depsipeptide Research

Ballard¹,

Yu²,

Wang³

2002

CMC

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This review focuses on the major developments in depsipeptide research since 1995. Depsipeptides are bio-oligomers composed of hydroxy and amino acids linked by amide and ester bonds. Many depsipeptides show very promising biological activities, including anticancer, antibacterial, antiviral, antifungal, anti-inflammatory, and anti-clotting or anti-antherogenic properties. In this report depsipeptides exhibiting these properties are discussed. Their isolation, structural determination, and notable structural features are discussed, but their biological properties and therapeutic potentials are emphasized. Depsipeptides have shown the greatest therapeutic potential as anticancer agents. Four depsipeptides have entered clinical trials for cancer treatment. Among the antiviral compounds discovered, the callipeltins and the quinoxapeptins are particularly promising due to their inhibitory activities against HIV. These compounds have the potential to be developed as anti-AIDS drugs or to serve as lead compounds for the discovery of structurally related anti-AIDS compounds. Antifungal compounds, such as the jaspamides, may lead to therapies against many of the opportunistic infections that accompany AIDS. Anti-inflammatory compounds such as SCH217048 act as neurokinin antagonists and may lead to anti-inflammatory treatments. Some depsipeptides such as micropeptins and A90720A have been found to be effective plasmin inhibitors, which have implications as treatments for cardiovascular diseases. Compounds such as SCH58149 help control the levels of HDL and LDL.

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“…Kahalalide F is a potent cytoxic compound extracted from Bryopsis sp. with described antitumoral, antiviral and antimalarial activity 216,217 . Zan et al 218 recently showed that kahalalides, including kahalalide F, are indeed produced by an obligate bacterial symbiont of the marine alga as defensive molecules that protect the host from herbivory.…”

Section: Green Macroalgae As Sources Of Bioactive Compoundsmentioning

confidence: 99%

“…with described antitumoral, antiviral and antimalarial activity. 216,217 Zan et al 218 recently showed that kahalalides, including kahalalide F, are indeed produced by an obligate bacterial symbiont of the marine alga as defensive molecules that protect the host from herbivory. The mollusc Elysia rufescens that feeds on Bryopsis is tolerant to kahalalides and hijacks these molecules using them for its own defence against predation.…”

Section: Secondary Metabolitesmentioning

confidence: 99%

The underexplored potential of green macroalgae in aquaculture

Moreira

Cruz

Marques

et al. 2021

Reviews in Aquaculture

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Green macroalgae (Chlorophyta) currently represent a residual fraction (<1%) of global seaweed biomass production landings. In turn, red (Rhodophyta) and brown (Ochrophyta) macroalgae dominate the remaining percentage of aquaculture production, exceeding 32 million tonnes per annum. However, the industry relies on a relatively low number of species, in which as few as seven macroalgal genera collectively represent the bulk of global production metrics. At present, innovation and increased sustainability of the industry calls for diversification of macroalgal species/strains in aquaculture to counteract potential adverse effects ensuing from genetic impoverishment, decreased resilience to disease and climate change. Despite the dominance of red and brown seaweed regarding production figures, aquaculture of green macroalgae has witnessed an increasing trend in productivity and diversification over the last decades, particularly in Asia, where green seaweed taxa often occupy specific market niches in the food sector. Furthermore, growing interest in green seaweeds in aquaculture has been highlighted for different applications in emerging western markets (eg IMTA, biorefineries, food delicacies), owing to a unique diversity of cytomorphologies, ecophysiological traits, propagation capacities and bioactive compounds featured by this group of macroalgae. Cultivation technologies are relatively well developed, but sustainability assessments are scarce and required to unlock the potential of green seaweeds. Although it is likely that green macroalgae will remain occupying specialised market niches, in which high‐value products are favoured, we argue that aquaculture of chlorophytan taxa presents itself as a compelling option under the current quest for commercial diversification of products and expansion of the sector.

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Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp

Cited by 9 publications

References 0 publications

Antimycobacterial natural products

Antimycobacterial natural products

Recent Developments in Depsipeptide Research

The underexplored potential of green macroalgae in aquaculture

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