Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population

Jang, Hyo-Min; Park, Keontae; Noh, Hyun-Deok; Lee, So-Hyeon; Kim, Dong-Hyun

doi:10.1016/j.intimp.2019.05.008

Cited by 33 publications

(10 citation statements)

References 35 publications

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“…In addition, we found that taxifolin increased the abundance of Firmicutes and decreased the abundance of Bacteroidetes of mice. Low abundance of Firmicutes microbiota can increase intestinal sensitivity to inflammation [ 59 , 60 , 61 ], suggesting that taxifolin could play an anti-inflammatory role in the intestinal tract by regulating intestinal microbiota imbalance. More importantly, a large number of the top 20 genera, 8 beneficial bacteria were significantly enriched after Taxifolin treatment, and 6 of them belong to SCFA-producing bacteria, such as Ruminiclostridium_5 , Bacteroides , Lachnospiraceae_NK4A136_group , Lactobacillus , Ruminococcaceae_UCG-014 , [ Eubacterium]_coprostanoligenes_group [ 62 , 63 , 64 , 65 , 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid

Zhang

et al. 2022

Nutrients

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Taxifolin is a bioflavonoid which has been used to treat Inflammatory Bowel Disease. However, taxifolin on DSS-induced colitis and gut health is still unclear. Here, we studied the effect of taxifolin on DSS-induced intestinal mucositis in mice. We measured the degree of intestinal mucosal injury and inflammatory response in DSS treated mice with or without taxifolin administration and studied the changes of fecal metabolites and intestinal microflora using 16S rRNA. The mechanism was further explored by fecal microbiota transplantation. The results showed that the weight loss and diarrhea score of the mice treated with taxifolin decreased in DSS-induced mice and longer colon length was displayed after taxifolin supplementation. Meanwhile, the expression of GPR41 and GPR43 in the colon was significantly increased by taxifolin treatment. Moreover, the expression of TNF-α, IL-1β, and IL-6 in colon tissue was inhibited by taxifolin treatment. The fecal metabolism pattern changed significantly after DSS treatment, which was reversed by taxifolin treatment. Importantly, taxifolin significantly increased the levels of butyric acid and isobutyric acid in the feces of DSS-treated mice. In terms of gut flora, taxifolin reversed the changes of Akkermansia, and further decreased uncultured_bacterium_f_Muribaculaceae. Fecal transplantation from taxifolin-treated mice showed a lower diarrhea score, reduced inflammatory response in the colon, and reduced intestinal mucosal damage, which may be related to the increased level of butyric acid in fecal metabolites. In conclusion, this study provides evidence that taxifolin can ameliorate DSS-induced colitis by altering gut microbiota to increase the production of SCFAs.

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Section: Discussionmentioning

confidence: 99%

Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid

Zhang

et al. 2022

Nutrients

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“…Li Xiao-bo from Shanghai Jiao Tong University mainly focused on the GM of spleen deficiency syndrome and the intervention mechanism of Sijunzi decoction ( Peng et al., 2020 ; Ma et al., 2021 ). Kim, Hojun from Dongguk University was mainly engaged in the research of TCM to improve obesity and metabolic syndrome by regulating GM ( Kim et al., 2014 ; Hussain et al., 2016 ), while Kim, Dong-hyun from Kyung Hee University was busy studying the role of TCM metabolites in the treatment of diseases such as colitis ( Kim et al., 2008 ; Jang et al., 2019 ). In terms of the impact of papers, Tong Xiao-lin from China Academy of Chinese Medical Sciences had the highest TC, who has long been engaged in clinical and scientific research on diabetes and its complications.…”

Section: Discussionmentioning

confidence: 99%

“…Bofutsushosan can alter the GM by increasing Akkermansia muciniphila , and help reduce diet-induced inflammation ( Fujisaka et al., 2020 ). Furthermore, the metabolism of GM also plays an important role in the anti-inflammatory effect of TCM ( Piwowarski et al., 2014 ; Jang et al., 2019 ). (2) Anti-oxidative stress: There is growing evidence that some bacteria, such as Lactobacillus , Bifidobacterium and Akkermansia , and the bacterial metabolite butyrate have potential anti-oxidant properties, and as mentioned above, TCM can promote their increase.…”

Section: Discussionmentioning

confidence: 99%

The interactions between traditional Chinese medicine and gut microbiota: Global research status and trends

Yang

Hao

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundThere is a crosstalk between traditional Chinese medicine (TCM) and gut microbiota (GM), many articles have studied and discussed the relationship between the two. The purpose of this study is to use bibliometric analysis to explore the research status and development trends of the TCM/GM research, identify and analyze the highly cited papers relating to the TCM/GM.MethodsA literature search regarding TCM/GM publications from 2004 to 2021 was undertaken on August 13, 2022. The main information (full record and cited references) of publications was extracted from the Science Citation Index Expanded (SCI-E) of Web of Science Core Collection (WoSCC). The Bibliometrix of R package, CiteSpace and VOSviewer were used for bibliometric analysis.ResultsA total of 830 papers were included. The publication years of papers were from 2004 to 2021. The number of papers had increased rapidly since 2018. China had the most publications and made most contributions to this field. Nanjing University of Chinese Medicine and Beijing University of Chinese Medicine were in the leading productive position in TCM/GM research, Chinese Academy of Chinese Medical Sciences had the highest total citations (TC). Duan Jin-ao from Nanjing University of Chinese Medicine had the largest number of publications, and Tong Xiao-lin from China Academy of Chinese Medical Sciences had the most TC. The Journal of Ethnopharmacology had the most published papers and the most TC. The main themes in TCM/GM included the role of GM in TCM treatment of glucolipid metabolism diseases and lower gastrointestinal diseases; the mechanism of interactions between GM and TCM to treat diseases; the links between TCM/GM and metabolism; and the relationship between GM and oral bioavailability of TCM.ConclusionThis study gained insight into the research status, hotspots and trends of global TCM/GM research, identified the most cited articles in TCM/GM and analyzed their characteristics, which may inform clinical researchers and practitioners’ future directions.

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“…Literature search results also showed that, all 11 main active compounds of Huashi Baidu Decoction (HSBD): quercetin, 31 luteolin, 32 kaempferol, 33 naringenin, 34 β-sitosterol, 35 delphinidin, 36 isorhamnetin, 37 aloe-emodin, 38 irisolidone, 39 baicalein 40 and (+)-catechin 41 had anti-inflammatory and anti-acute lung injury effects. These literature data proved the results of our network pharmacology analysis.…”

Section: Discussionmentioning

confidence: 99%

Analyzing the potential therapeutic mechanism of Huashi Baidu Decoction on severe COVID-19 through integrating network pharmacological methods

Zhu

Yan

et al. 2021

Journal of Traditional and Complementary Medicine

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Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population

Cited by 33 publications

References 35 publications

Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid

Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid

The interactions between traditional Chinese medicine and gut microbiota: Global research status and trends

Analyzing the potential therapeutic mechanism of Huashi Baidu Decoction on severe COVID-19 through integrating network pharmacological methods

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