Karakter Solid Lipid Nano Particle (SLN) – Ubiquinon (Q10) dengan Beda Jenis Kosurfaktan: Poloxamer 188, Lesitin, Propilen Glikol

Rosita, Noorma; A’Yunin, Qurrotu; Hendradi, Esti

doi:10.20473/jfiki.v6i12019.17-24

Cited by 4 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides that, it can produce small particle sizes because they have a smaller surface tension but concentration and technique for producing SLM need to be considered. [ 11 ] Melt o/w emulsification technique shows that quercetin SLM can be formulated as a dry powder which is suitable for the delivery of inhaled drugs, apart from that it is easier and can provide good entrapment results.…”

Section: Introductionmentioning

confidence: 99%

Characterization and in vitro release of inhalation quercetin solid lipid microparticles

Rosita

Ambarwati

Erawati

et al. 2022

Journal of Advanced Pharmaceutical Technology &Amp; Research

View full text Add to dashboard Cite

This study purposes to develop solid lipid microparticles (SLM) inhalation delivery system for respiratory diseases with Quercetin as the active agent. Quercetin has various functions, such as for antioxidant, anti-inflammatory, immunomodulator, and antivirus. SLM is formed from a mixture of lipids and surfactants, namely, Glyceryl Behenate as solid lipid, Poloxamer 188 as the surfactant, and production of SLM using the melt o/w emulsification technique and was dried using freeze dryer. The effect of lipid concentration was studied in this research. Quercetin SLM was characterized by moisture content, Fourier transform infrared, particle size, yield, drug loading, and encapsulation efficiency. The SLM particles produced were spherical in shape and had a smooth surface with sizes of F1, F2, and F3 were 1.79 μm, 1.88 μm, and 1.91 μm, respectively. According to the target particle size of inhalation, Quercetin SLM had good flowability according to Carr's Index (F1 = 12.73% ± 0.38, F2 = 14.28% ± 0.65, F3 = 14.65% ± 0.62), in which the highest drug loading and EE of F3 were 10.94% and 88.48%, respectively. In vitro release study showed that in 630 min about 31%–33% Quercetin released indicated sustained release following Higuchi kinetics and quercetin release rate was not affected by the amount of lipid. To sum up, quercetin SLM demonstrates its potential as an inhalation delivery system and it is recommended to study its stability.

show abstract

Section: Introductionmentioning

confidence: 99%

Characterization and in vitro release of inhalation quercetin solid lipid microparticles

Rosita

Ambarwati

Erawati

et al. 2022

Journal of Advanced Pharmaceutical Technology &Amp; Research

View full text Add to dashboard Cite

show abstract

“…This is presumably because the HLB value is quite large, namely 29, so it works more effectively on the water phase which is the outer phase of the system. Particles surrounded by poloxamer 188 become more difficult to combine with each other, so the system becomes more stable [4]. With the advancement of science and technology, there are many methods that can be used to increase solubility, one of which is nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Ball Ratio in Planetary Ballmill in Nimodipine-poloxamer 188 Nanoparticle Formulation Process

Wahyuni¹,

Makmur²,

Putri³

2022

IJPSM

View full text Add to dashboard Cite

Nimodipine is a drug that belongs to the class II biopharmaceutical classification system which has low solubility with high permeability. The ball mill ratio is a factor that affects the results of milling using a planetary ballmill. This study aims to see the optimal ball ratio in the milling process with a planetary ball mill in the physicochemical characterization of nimodipine-poloxamer 188 nanoparticles and their dissolution rate. Milling in a planetary ball mill was carried out using zirconium balls at a ratio of 20%, 25%, and 30% to the volume of the vessel respectively for 1, 2, and 3 nanoparticles. The characterization of nanoparticles includes PSA with the results showing a reduction in particle size, XRD there is a decrease in peak intensity, DSC there is a decrease in melting point, FT-IR doesn’t change the wave number, SEM shows morphologically a change in shape, TLC indicates no chemical interaction, in the assay, the percentage of nimodipine and nanoparticles 1,2,3 was respectively 98.91%, 99.85%, 100.73%, 99.31%. the solubility test of nimodipine and nanoparticles 1,2,3, respectively 0.3390 g/ml, 19.8698 g/ml, 6.0673 g/ml, 8.4405 g/ml, and the dissolution test showed an increase in the 60th minute of nanoparticles 1,2 and 3 respectively 61,5841%, 52,3159%, 56,6027% compared with 23.3978% pure nimodipine. The results of the ANOVA test of solubility and dissolution rate showed that there was a significant difference between nimodipine-poloxamer 188 nanoparticles and pure nimodipine.

show abstract

“…(3) total weight of SLM powder where W total active is total amount of AA added to the system, W free active is the analyzed amount of free active. The values were averaged on three determinations (Jaspart et al, 2005;Rahimpour et al, 2016;Rosita et al, 2019).…”

Section: Entrapment Efficiency and Active Loadingmentioning

confidence: 99%

“…This may be because poloxamer 188 can effectively reduce the surface tension between the lipid phase and the aqueous phase during emulsification, resulting in a spherical particle shape. Moreover, the steric effect of poloxamer 188 could prevent a droplet agglomeration (Hariyadi et al, 2022;Rosita et al, 2019), hence the AASLMs stabilized by poloxamer 188 showed comparable particle shape before and after freezedrying. Our results were consistent with the study of Hariya (2022) which demonstrated that SLMs made of glyceryl behenate with poloxamer 188, to deliver quercetin, had a spherical morphology (Hariyadi et al, 2022).…”

Section: Powder Appearancementioning

confidence: 99%

Effects of lipids and surfactants on the characteristics of asiatic acid-loaded solid lipid microparticles

Witarat

View full text Add to dashboard Cite

The objective of this study was to evaluate the effects of solid lipids: beeswax and cetyl alcohol, and surfactants: Tween 80?, soybean lecithin and poloxamer 188 on the characteristics of solid lipid microparticles containing asiatic acid (AASLM). The AASLM were prepared from 10% or 15% of beeswax or cetyl alcohol together with 3% of surfactant F1-F12) by melt dispersion cum freeze-drying technique to obtain a solid dosage form. The physicochemical characteristics of the AASLM powders, including appearance, surface morphology, particle size, %labeled amount of asiatic acid (AA) and %entrapment efficiency (EE) were evaluated. The results revealed that AASLM prepared from 10% or 15% beeswax with 3% soybean lecithin (F2 and F8) could not yield a dry powder form, whereas those with Tween 80? (Tw80) or poloxamer 188 (F1, F3, F7 and F9) appeared as white to slightly yellowish coarse powders. AASLM were prepared from 10% or 15% cetyl alcohol with Tw80 or soybean lecithin or poloxamer 188 and appeared as white fine powders (F4, F5, F6, F10, F11, F12). The mean particle sizes of obtaining AASLM powders ranged from 7.46?0.08 to 38.86?0.34 microns. The surface morphology of AASLM powders, was examined by scanning electron microscope, showed a non-spherical shape. The morphology of AASLM dispersions before freeze-drying and after redispersion of the freeze-dried powder were also investigated using the optical microscope. In all the dispersions, the AASLM prepared from beeswax or cetyl alcohol with poloxamer 188 (F3, F6, F9, F12) had spherical shape, whereas those prepared from beeswax with Tw80 or soybean lecithin (F1, F7, F5, F11) and cetyl alcohol with Tw80 (F4, F10) seemed to have irregular shape. The %labeled amount of AASLMs ranged from 90.43?0.02% to 95.38?0.02% which were considered acceptable. The %EE of resultant AASLMs ranged from 53.75?0.01% to 100.00?0.00%. It was found that F3, F6, F9, F12 could entrap Asiatic acid of 100%. Therefore, it could be concluded that AASLM prepared with beeswax or cetyl alcohol with poloxamer 188 has the greatest potential among the test formulations as a topical carrier for AA. Further studies should be conducted to explore its utilization in cosmetics.

show abstract

Karakter Solid Lipid Nano Particle (SLN) – Ubiquinon (Q10) dengan Beda Jenis Kosurfaktan: Poloxamer 188, Lesitin, Propilen Glikol

Cited by 4 publications

References 16 publications

Characterization and in vitro release of inhalation quercetin solid lipid microparticles

Characterization and in vitro release of inhalation quercetin solid lipid microparticles

Optimization of Ball Ratio in Planetary Ballmill in Nimodipine-poloxamer 188 Nanoparticle Formulation Process

Effects of lipids and surfactants on the characteristics of asiatic acid-loaded solid lipid microparticles

Contact Info

Product

Resources

About