Karyomegalic interstitial nephritis

Godin, Michel; François, Arnaud; Roy, F. Le; Morin, Jean–Paul; Creppy, Edmond E.; Hémet, J; Fillastre, J P

doi:10.1016/s0272-6386(96)90047-5

Cited by 39 publications

(27 citation statements)

References 2 publications

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“…, found in two siblings with renal failure in France (Godin et al 1996). Patients in Egypt with end stage renal disease (not undergoing dialysis) or nephritic syndrome had significantly higher levels of urinary OTA (means 1.9 and 3.1 ng ml À1 ) than two reference groups (0.26 and 0.01 ng ml À1 ) (Wafa et al 1998).…”

mentioning

confidence: 80%

Biomarkers of human exposure to ochratoxin A

Scott

2005

Food Additives & Contaminants

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mentioning

confidence: 80%

Biomarkers of human exposure to ochratoxin A

Scott

2005

Food Additives & Contaminants

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“…The highest incidence of detectable OTA exposures in urine, 100%, were found by Petkova-Bocharova et al (Petkova-Bocharova et al, 2003) in a BEN-endemic region and in non-endemic regions including Portugal (Duarte et al, 2010b) and Italy (Breitholtz-Emanuelsson et al, 1994). The highest recorded levels of OTA in urine, 367 ng/ml and 1801 ng/ml, were found in two French siblings with renal failure (Godin et al, 1996). Petkova-Bocharova et al (2003) and Castegnaro et al (2006) applied similar methodology as Gilbert et al (2001) when studying 16 human participants (Castegnaro et al, 2006).…”

Section: Background: Risk Assessment Of Ochratoxin Amentioning

confidence: 97%

Ochratoxin A and Human Health Risk: A Review of the Evidence

Bui-Klimke

2014

Critical Reviews in Food Science and Nutrition

328

162

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Ochratoxin A (OTA) is a mycotoxin produced by several fungal species including Aspergillus ochraceus, A. carbonarius, A. niger and Penicillium verrucosum. OTA causes nephrotoxicity and renal tumors in a variety of animal species; however, human health effects are less well-characterized. Various studies have linked OTA exposure with the human diseases Balkan endemic nephropathy (BEN) and chronic interstitial nephropathy (CIN), as well as other renal diseases. This study reviews the epidemiological literature on OTA exposure and adverse health effects in different populations worldwide, and assesses the potential human health risks of OTA exposure. Epidemiological studies identified in a systematic review were used to calculate unadjusted odds ratios for OTA associated with various health endpoints. With one exception, there appears to be no statistically significant evidence for human health risks associated with OTA exposure. One Egyptian study showed a significantly higher risk of nephritic syndrome in those with very high urinary OTA levels compared with relatively unexposed individuals; however, other potential risk factors were not controlled for in the study. Larger cohort or case-control studies are needed in the future to better establish potential OTA-related human health effects, and further duplicate-diet studies are needed to validate biomarkers of OTA exposure in humans.

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“…Major histocompatibility complex (MHC) typing revealed the A9/ B35 haptotype, which suggested a genetic defect in chromosome 6 that was linked to the MHC locus [8]. Godin et al [9] reported two cases of karyomegalic interstitial nephritis in siblings with ochratoxin and HLA haplotype A9/B35. …”

Section: Discussionmentioning

confidence: 99%