Karyotypic differentiation in a spontaneous mouse B-cell leukemia

Cytogenetic studies on B‐cell leukemias of akr origin

“…This deletion is similar to Type I11 of deleted chromosome 2, typical of myeloid leukemias (Hayata et al, 1979(Hayata et al, , 1983. Among the 15 tumors analyzed in the present study we did not observe any trisomy of chromosome 15, in contrast to the demonstration of chromosome 15 trisomy among spontaneous and chemically induced B-cell leukemias in other studies (Schroder et al, 1979;Fialkov et al, 1980;Wiener et al, 1981).…”

Immunobiology of a Spontaneous Murine B Cell Leukemia (BCL1)

“…A third cell line was found in the fifth passage when the leukemia was very malignant, and had only 35 chromosomes. Reciprocal translocations 4; 15 and X;8 occurred in all these cell lines (Schroder et al 1979). Therefore, it seems reasonable lo assume that the line (clone) with 39 chromosomes was the precursor ofthe two other clones.…”

“…The karyotypes were studied in lymphocytes from normal BALB/c mice, and in cells from leukemic mice in the first and fifth passage of PBL in unirradiated BALB/C hosts (Schroder et al 1979). Suspensions of lymphocytes from peripheral blood (leukemic mice) or spleen (controls) were obtained after centrifugation on a Ficoll-Hypaque gradient.…”

“…The fact that they have taken over is probably a consequence of their superior growth pattern. Whether the 17; 19 translocation found at a time when the tumor became very malignant (Schroder et al 1979) is a primary event responsible for the increased malignancy or a secondary phenomenon is not known. In the case of induced leukemias associated with trisomy 15, passage of leukemic cells also often led to rapid growth of the tumor in recipient animals (Wiener et al 1978).…”

Clonal origin and trisomy of chromosome 15 in murine B‐cell malignancies

“…These findings contrast with previously reported cytogenetic abnormalities in other murine B-cell neoplasms. In those investigations, breakage of chromosome 15 and its translocation to other chromosomes was seen in murine plasmacytomas (Shepard et al, 1978;Yoshida et al, 1978), and also in a spontaneous B-cell leukemia (Shroeder et al, 1979). Whether these discrepancies in karyotypic abnormalities observed in B-lymphoid malignancies are related to different stages of differentiation of the neoplastic cells, to etiological differences or to other factors is not clear.…”